12.doctors often try to reduce the symptoms of gluconeogenesis deficiencies by prescribing thiamine and lipoic acid supplements. which enzyme/complex would these supplements target and why?

Answers

Answer 1

Doctors typically target the Pyruvate dehydrogenase complex with thiamine and lipoic acid supplements to reduce the symptoms of gluconeogenesis deficiencies. Here option D is the correct answer.

The Pyruvate dehydrogenase complex is a key enzymatic complex involved in the conversion of pyruvate to acetyl-CoA, which is an essential step in the production of glucose during gluconeogenesis. This complex consists of multiple components, including pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase.

Thiamine, also known as vitamin B1, plays a vital role as a cofactor for the enzyme pyruvate dehydrogenase. Thiamine pyrophosphate (TPP), the active form of thiamine, is involved in the decarboxylation of pyruvate by pyruvate dehydrogenase. By supplementing with thiamine, the activity of the pyruvate dehydrogenase complex can be enhanced, allowing for a more efficient conversion of pyruvate to acetyl-CoA.

Lipoic acid, an antioxidant, and cofactor, is another important component of the Pyruvate dehydrogenase complex. It is covalently attached to the dihydrolipoamide transacetylase component and acts as a carrier of acetyl groups during the reaction. Lipoic acid supplementation helps maintain the integrity and activity of the Pyruvate dehydrogenase complex, ensuring proper function in the gluconeogenesis pathway.

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Complete question:

Which enzyme/complex do doctors typically target with thiamine and lipoic acid supplements to reduce the symptoms of gluconeogenesis deficiencies?

A) Pyruvate carboxylase

B) Phosphoenolpyruvate carboxykinase

C) Fructose-1,6-bisphosphatase

D) Pyruvate dehydrogenase complex


Related Questions

Do the benefits seem to outweigh the risks of genetically modifying about the glittering gold seahorse Explain your rationale.

plz help ​

Answers

Answer:

yes it does

Explanation:

Which hormones causes ejection of milk making it accessible for the infant?

Answers

Answer:

Oxytocin.

Explanation:

Oxytocin causes ejection of milk making it accessible for the infant.
“Oxytocin. The oxytocin reflex is also sometimes called the “letdown reflex” or the “milk ejection reflex”. Oxytocin is produced more quickly than prolactin. It makes the milk that is already in the breast flow for the current feed, and helps the baby to get the milk easily.”


hope this helps!

Over several generations,a species of insect becomes resistant to a pesticide that farmers commonly use.what type of selection is this an example of,and why
Select one
Artificial selection,because only individuals with the resistant trait survive

Answers

The type of selection where a species of insect becomes resistant to a pesticide that farmers commonly use is Natural selection.

What describes naturakl selection?

Natural selection is the process by which organisms with traits that are better suited to their environment are more likely to survive and reproduce. In this case, the insects that are resistant to the pesticide are more likely to survive and reproduce, because they are not killed by the pesticide.

This means that the next generation of insects will have more resistant individuals. Over time, this can lead to a population of insects that is completely resistant to the pesticide.

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Cardiac output is the amount of blood pumped by the heart in one minute. Which of these will increase cardiac output?

Answers

Answer: the factors that increase cardiac output include:

--> Nervous stimulation and

--> Hypertrophy of the heart.

Explanation:

Cardiac output can be defined as the quantity of blood pumped into the aorta each minute by the heart. This is also the quantity of blood that flows through the circulation. There are factors that can cause increased cardiac output or that can lead to a hypereffective heart. They are:

--> NERVOUS STIMULATION: The combination of sympathetic stimulation and parasympathetic inhibition does two things to increase the pumping effectiveness or cardiac output of the heart. These include:

• it greatly increase the heart rate from the normal level of 72 beats/mum up to 180 to 200 beats /mom.

• it increases the strength of heart contraction, which is called increased contractility to twice it's normal strength.

--> HYPERTROPHY OF THE HEART: A long term increased workload, but not so much excess load that it damages the heart, causes the heart muscle to increase in mass and contractile strength in the same way that heavy exercise causes skeletal muscles to hypertrophy. This effect of increased muscle mass of the heart, allows the heart to pump much greater than usual amounts of cardiac output.

The state of flux in modern systematic groupings could best be described as/seen in a variety of conflicting kingdom or _____ structures.

Answers

The state of flux in modern systematic groupings can be seen in a variety of conflicting kingdom or domain structures.


The classification of organisms into different taxonomic categories, such as kingdoms or domains, is constantly evolving as new scientific discoveries and advancements are made. The traditional five-kingdom system (Animalia, Plantae, Fungi, Protista, and Monera) has been challenged and modified in light of new genetic and molecular information.

One major development in the field of taxonomy is the adoption of the three-domain system, proposed by Carl Woese in the 1990s. This system categorizes organisms into three domains: Bacteria, Archaea, and Eukarya. This classification is based on the genetic and biochemical differences observed in the ribosomal RNA sequences of these organisms. The three-domain system highlights the fundamental distinction between prokaryotic (Bacteria and Archaea) and eukaryotic (Eukarya) organisms.

However, even within these domains, there is ongoing debate and reorganization at lower taxonomic levels. For example, the classification of certain groups within the domain Eukarya, such as protists, has been challenging due to their vast diversity and complex evolutionary relationships. Protists were traditionally considered a single kingdom, but they are now recognized as a polyphyletic group, comprising multiple lineages that are not closely related.

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Which of the following is not included in a bill of sale.

A) A detailed description of the item

B) The make, model, and color of an item

C) A specific set of rights to the buyer

D) Signatures of both parties

Answers

i believe it would be c. everything else on the list is mandatory

How is the ocean affected by the releasing of excess carbon?

Answers

Answer:

Explanation:

Because of human-driven increased levels of carbon dioxide in the atmosphere, there is more CO2 dissolving into the ocean. The ocean's average pH is now around 8.1 , which is basic (or alkaline), but as the ocean continues to absorb more CO2, the pH decreases and the ocean becomes more acidic.

If a strand of DNA has the nucleotide sequence: AATGCT, what is the complementary sequence of RNA nucleotides that would be made from it?

Answers

Answer:

Explanation:

All the best

How did the animals near orchard park all die

Answers

Answer:

Scientists have shown that the ash that killed and eventually buried the animals at the park blew eastward from a huge volcanic eruption in what is now southwestern Idaho.

Which of the following is NOT an aspect of organisms found in the Plant Kingdom?

Movement

Sexual Reproduction


Multi-Celled


Autotrophic (Makes its own food)

Answers

Movement sorry if wrong

La división celular sucede en 2 fases, en primer la lugar la división del ______________ y después la división del __________________ *

Answers

No idea what this means

With respect to climate change and natural selection acting upon a population of one species of frog in a tropical rain forest, mutations of DNA sequences of the frog genome that are inherited by offspring It is estimated by a wide body of scientists that in recent decades we have begun another mass extinction event on Earth. Amphibians in particular have been in decline, sometimes due to climate change, and they therefore provide a possible early sign of dramatic biodiversity change to come. With respect to climate change and natural selection acting upon a population of one species of frog in a tropical rain forest, mutations of DNA sequences of the frog genome that are inherited by offspring may have no effect at all, be beneficial, or be harmful. will primarily be harmful. will only speed the decline and extinction of the species. could either be beneficial or harmful.

Answers

Answer:

be beneficial.

Explanation:

Mutations of DNA sequences of the frog genome that are inherited by offspring will be beneficial for the frog because this mutation in the genetic makeup of frog provides resistance in this new environmental conditions. This mutation occurs due to the exposure of cell's DNA to the environmental factor which gives benefit to the organisms to survive different condition which can't tolerate by their parents so this mutation is beneficial for that offspring of frog.

please help tephographic map

Answers

Answer:

1 weathering 2 erosion 3 deposition

Explanation:

assuming this portrays a mountain the rain starts at the top eroding down the mountain carrying any sediment and then is deposited at the base

Help me please please

Answers

Answer:

use a search engine

Explanation:

the internet is a great way to answer these simply type in your term EX: Sun definition. and paraphrase the answer. so instead of the star around which the earth orbits you can say the sun is a star that keeps all planets in our solar system in orbit

Explain how cells respond to hormonal stimulation, and refer to
enhancement of
survival and reproduction of the plant

Answers

Cells respond to hormonal stimulation by activating specific signaling pathways that trigger a series of molecular and physiological responses.

When a hormone binds to its receptor on the cell surface or inside the cell, it initiates a cascade of events that ultimately lead to changes in gene expression and cellular activities.

These responses are crucial for the enhancement of the survival and reproduction of the plant.

Upon hormonal stimulation, signal transduction pathways are activated, which can involve the activation of second messengers, protein kinases, and transcription factors.

These molecular components relay the hormonal signal from the receptor to the nucleus, where gene expression is modulated. The altered gene expression leads to the synthesis of proteins that play essential roles in the plant's survival and reproduction.

For example, hormone-induced gene expression can regulate processes such as seed germination, flowering, fruit development, and stress responses. These responses are essential for the plant's adaptation to its environment, ensuring its survival in challenging conditions and promoting reproductive success.

Furthermore, hormones also influence cellular processes related to plant reproduction. They regulate the development of reproductive structures, such as flowers, and influence the timing of flowering. Hormones also play a role in pollination, fertilization, and seed development.

For instance, auxins and gibberellins are involved in promoting flower and fruit development, while abscisic acid influences seed dormancy and germination.

By modulating these reproductive processes, hormones contribute to the successful reproduction and propagation of the plant species.

In summary, cells respond to hormonal stimulation by activating specific signaling pathways, leading to changes in gene expression and cellular activities.

These responses are crucial for enhancing the survival and reproduction of plants, enabling them to adapt to their environment, and ensuring successful reproduction and propagation of the species.

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You catch, tag, and release 35 fish back into a pond. Then, you catch 70 more fish, 12 of which have tags on them,
What is the best estimate of the number of fish in the pond?
a 100
b 150
c 142
d 204

Answers

Answer:

100

Explanation:

70 + 35 is 105 and if the 12 fish were new it would be 117 which is almost 25 away from 142 but 17 away from 100. hope that makes since!  

Answer:

204 d

Explanation: took the test

Which of the following is NOT true regarding cross-sectional studies? (2 points)
A. Good for generating hypotheses.
B. Not used for diseases that are rare or of short duration.
C. Permit the determination of population characteristics.
D. The temporal relationship between exposure and disease can be determined.

Answers

The temporal relationship between exposure and disease can be determined, option D is correct.

Cross-sectional studies are not suitable for determining the temporal relationship between exposure and disease. Cross-sectional studies provide a snapshot of data collected at a specific point in time, capturing information on both exposure and disease prevalence simultaneously. However, they do not follow individuals over time to establish a cause-and-effect relationship. Since cross-sectional studies collect data at a single time point, they cannot determine the sequence of events or whether exposure preceded the disease.

To establish temporal relationships, longitudinal studies are typically employed, where individuals are followed over time to assess exposures and track the development of diseases, allowing for better assessment of causality and temporal associations between exposure and outcome, option D is correct.

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The Tibetans and Han Chinese share several genetic traits and DNA. However, the EPAS1 gene, which increases the ability of red blood cells to carry oxygen even in low oxygen environments, is only commonly found in the Tibetan population that live in higher elevations. Explain why this gene is only common in Tibetan populations from the perspective of competitive advantage and natural selection. Write your answer in three to five sentences.(4 points)

Answers

Answer:

When in higher altitudes, ticker blond has a tendency to cause problems like heart attack's, however the Tibetans have adapted to the high altitudes and this has made their blood thinner in order to keep them safe in the altitudes, including that it has low oxygen rates in the altitude therefore providing more oxygen in the bloods cells.  

Explanation:

:D It's not my best explanation but I hope this helps <3.

Owing to the fact that ability of the redblood cells to  to carry oxygen even in low oxygen environments is neccessary at high elevations, the Tibetan population that live in higher elevations are found to possess the EPAS1 gene.

What is natural selection?

The term natural selection refers to the fact that organisms that are better adapted to their habitat will live longer and reproduce. Now we have to note that owing to the elevation at which they live, the people that possess this EPAS1 gene can cope with oxygen stress that could likely occur at a high altitude.

As such, the Tibetan population that live in higher elevations are found to possess the EPAS1 gene.

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Can someone please help I need for finals to study

Answers

1st Page: Include separate in each question next time.

1) Carbon dioxide (CO2) is the greenhouse gas that has been most released into the atmosphere by human activity. Burning of fossil fuels like coal, oil, and natural gas for transportation, electricity generation, and other industrial processes releases large amounts of CO2 into the atmosphere. Deforestation and other land-use changes also contribute to increased CO2 emissions. CO2 is a major contributor to global warming and climate change, as it traps heat in the atmosphere and results in a warming effect on the planet. Other greenhouse gases, such as methane and nitrous oxide, also contribute to climate change, but CO2 is the most significant and has the greatest impact on the Earth's climate system.

2) The concept of the "heat trapping blanket" refers to the natural greenhouse effect that occurs in the Earth's atmosphere. The Earth's atmosphere acts like a blanket that traps some of the heat energy from the Sun that is absorbed by the Earth's surface, keeping the planet warm enough to support life. This is a natural and necessary process that has been occurring for billions of years. The Earth's atmosphere is made up of several gases, including carbon dioxide, methane, and water vapor, that have the ability to trap heat in the atmosphere. These gases are known as greenhouse gases because they act like the glass walls of a greenhouse, allowing sunlight to pass through but trapping the heat that is radiated back from the Earth's surface. activities, such as burning fossil fuels and deforestation, have increased the concentration of greenhouse gases in the atmosphere, particularly carbon dioxide. This has intensified the greenhouse effect, resulting in a warming of the Earth's surface temperatures, known as global warming. The "heat trapping blanket" analogy is often used to describe this process, as the increasing concentration of greenhouse gases in the atmosphere is like adding an extra layer to the blanket, making it thicker and trapping more heat. The consequences of global warming include rising sea levels, more frequent and severe weather events, and changes in the distribution of plant and animal species. In order to reduce the impact of global warming, it is important to reduce greenhouse gas emissions and promote sustainable practices that help to mitigate the effects of climate change.

3) The three "-spheres" that are being affected and changed by greenhouse gases are:

The atmosphere: Greenhouse gases such as carbon dioxide, methane, and nitrous oxide are accumulating in the atmosphere and trapping heat, causing the Earth's average temperature to rise. This is leading to changes in weather patterns, rising sea levels, and more frequent and severe weather events.

The hydrosphere: The increasing temperature of the Earth's atmosphere is causing the oceans to warm, leading to thermal expansion and rising sea levels. The oceans are also becoming more acidic due to the absorption of carbon dioxide from the atmosphere, which is having negative impacts on marine ecosystems.

The biosphere: Changes in temperature and weather patterns are affecting ecosystems and the distribution of plant and animal species. Some species are being forced to migrate to new areas in search of suitable habitats, while others are becoming endangered or extinct. The biosphere is also being impacted by ocean acidification, which can affect the ability of marine organisms to form shells and skeletons.

4) Reducing greenhouse gas emissions and mitigating the effects of climate change is a complex problem that requires a multi-faceted approach. Here are some potential strategies that could be used to address the issue, along with their criteria, constraints, and costs: Renewable energy: Transitioning to renewable energy sources such as solar, wind, and hydropower can reduce greenhouse gas emissions from fossil fuel use. Criteria for this solution could include the ability to generate electricity at scale, cost-effectiveness, and reliability. Constraints include the need for suitable locations for renewable energy infrastructure, limited storage capacity, and the intermittency of some renewable energy sources. Costs can vary depending on the specific technology used and the location of the infrastructure.

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what happened in the step immediately before the phase pictured here to cause this problem

Answers

Answer:

come again..not got the question

2. The formation of a new community where another community already exists is known as ______.
A primary succession
B secondary succession
C pioneer community
D pioneer species​

Answers

Answer:

B secondary succession

Explanation:

UNA FUENTE DE ALIMENTOS QUE SOLO LAS ARDILLAS SON IMPACTADAS TANTO EN EL ECOSISTEMA ??

A FOOD SOURCE THAT ONLY THD SQUIRRELS ARD IMPACTED THE ECOSYSTEM SO MUCH??

Answers

English please
I do not understand this gibberish

Why is earths interior layered?

Answers

The Earth is divided into three main layers. The dense, hot inner core (yellow), the molten outer core (orange), the mantle (red), and the thin crust (brown), which supports all life in the known universe.

What does it mean to ‘translate’ something? What is being translated in protein synthesis?

Answers

Answer:

Answer:

Translation is the process of translating the sequence of a messenger RNA  molecule to a sequence of amino acids during protein synthesis. The genetic code describes the relationship between the sequence of base pairs in a gene and the corresponding amino acid sequence that it encodes.

For a second i thought you meant to translate something to another language lol.

1- Define Photosynthesis.​

Answers

Answer: the process in which plants use sunlight to synthesize food from carbon dioxide and water.

Explanation:

the process by which green plants and some other organisms use sunlight to synthesize foods from carbon dioxide and water. Photosynthesis in plants generally involves the green pigment chlorophyll and generates oxygen as a byproduct.

HURRY IT’S TIMED I’LL GIVE YOU BRAINLIEST

Which illustrates the relationship between cooling magma and mineral formation?
A. Darwins theory
B. Theory of relativity
C. Bowen‘s reaction series
D. Newtons principle of physics

Answers

Answer: C. Bowen‘s reaction series

Explanation:

below are 4 terms. look at these terms. then, determine which of those 4 terms includes or incorporates the other 3 terms? terms to examine: (1) community, (2) population, (3) species, (4) ecosystem

Answers

The term "ecosystem" incorporates the other three terms: community, population, and species.

An ecosystem refers to a complex system where living organisms, their physical environment, and their interactions exist. Within an ecosystem, there are various levels of organization. At the lowest level, we have individual organisms of the same species, which form populations. Populations of different species then interact within a given area, forming a community. A community comprises different populations coexisting and interacting with each other. Lastly, an ecosystem includes both the biotic (living) and abiotic (non-living) components, encompassing all communities, populations, and species present within a specific geographic area. In this way, the concept of an ecosystem incorporates and integrates the interactions and relationships between communities, populations, and species, providing a holistic understanding of the environment.

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Select the correct answer. Which of the following is an example of an amphiarthrotic joint?
a. suture
b. elbow
c. hip
d. interosseous membrane

Answers

The correct option is d. interosseous membrane . An interosseous membrane is an example of an amphiarthrotic joint.

The interosseous membrane is a fibrous connective tissue structure that spans between two adjacent long bones in the body, providing stability and transmitting forces between them. It is most commonly found between the radius and ulna in the forearm and the tibia and fibula in the lower leg.

The interosseous membrane acts as a flexible barrier, maintaining the appropriate distance and alignment between the bones while allowing a limited degree of movement. It helps distribute forces generated during activities such as weight-bearing, gripping, or rotational movements across the two bones, preventing excessive stress on any one bone.

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At a certain age the brain takes over your writing skills, it becomes a subconscious task.
True or False?

Answers

The answer is false the brain always had control it doesn’t just take over at a certain age.
Hope this helps:)

Question 1. What change led to an increase in the number of light-colored moths within the population?
1. More mutations
2. Decreased pollution
3. More dark colored trees
4. Fewer humans

Question 2. Claim: Individuals in a population have genetic variations that can be passed on to their offspring. Refer back to the rabbits in the desert from the natural selection activity we did in class. How could an organism's traits influence the survival rate of the population?

Answers

Answer: 1. 1. More mutations. 2. According to Charles Darwin's theory of evolution by natural selection, organisms that possess heritable traits that enable them to better adapt to their environment compared with other members of their species will be more likely to survive, reproduce, and pass more of their genes on to the next generation.

Explanation:

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Ms. Marcia Brady lives and works in Prince Edward Island. She owns and operates a No Frills grocery store, which is an HST registrant. During the current year, her business has total revenue of $1775410. 34% of the total revenue is from the sale of fully taxable supplies. 41% of the total revenue is from the sale of zero-rated supplies. The total revenue balance includes applicable HST.Rent for the period on her store was $24000 and she pays a clerical assistant an annual salary of $28,500. Her capital expenditures during the period are for new shelving with a cost of $40000 and computer point-of-sale hardware for $60000. All expenditure amounts are before HST. The current expenditures and all the assets are used 86% for the provision of taxable supplies. 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Do not indent manually.) Michael's dog stands 10 feet from a table, and notices a plate resting on the edge of the table. The height from the ground to the top of the table is 4 feet, and his dog's eyes are 1 foot above the ground. What is the angle of elevation from Michael's dog to the plate? Round your answer to the nearest whole degree. Owen runs 37 miles every 2 weeks. Enter the number of miles Owen runs in 12 weeks Which of the following statements accurately describe the HarlemRenaissance?1. It was a period of outstanding literary creativity.II. It helped redefine African-American expression.III. It was a result of the great migration of African Americans from southernto northern cities.IV. It took place from 1941 to 1949.OA. I and Ill onlyB. I, II, and Ill onlyOC. II and IV onlyD. I, II, and IV onlyE. II, III, and IV only Tuition for one year at Mount Tusk University is $13,400. Elijah has saved$1,800 for this year's tuition. His parents have agreed to pay $5,000 thisyear, and he earned a football scholarship for $3,500. Elijah hopes to earnthe rest of the money through his work-study job tutoring in the mathcenter. How much money does Elijah need to earn tutoring? (Enter thequantity only) *Your answer What is the function of the flower of a plant? construction cost 130.000 $ X $annual expenses 12.000 $ 14.000 $salvage value 18.000 $ 20.000 $physical life 30 years 32 yearsIf you consider uniform annual cost values, what is the maximum value of X to make the Project B cheaper.