Bloom syndrome is an autosomal recessive disease that exhibits haploinsufficiency. A recent survey showed that people heterozygous for mutations at the BLM locus are at increased risk of colon cancer. Suppose you are a genetic counselor. A young woman is referred to you whose mother has Bloom syndrome; the young woman's father has no family history of Bloom syndrome. The young woman asks whether she is likely to experience any other health problems associated with her family history of Bloom syndrome. What advice would you give her?

Answers

Answer 1

Answer:

The correct answer is - she is heterozygous for a mutated BLM allele and will have an increased risk of colon cancer.

Explanation:

Autosomal recessive disease expresses itself in next-generation only if there is both alleles are recessive for the gene. In haploinsufficiency, the dominant allele fails to express itself in the phenotype due to insufficiency. So, if even one allele of the recessive gene present in the haploinsufficiency case, it will affect and express its trait.

She is heterozygous for a blood syndrome, as her mother had but her father has no disease, allele and will have an increased risk of colon cancer.


Related Questions

I’m thinking both what do you all think??

Answers

Answer:

I actually think a chemical change

Explanation:

The chemical composition should not change in a physical change so therefore I think it’s only a chemical change

Which list correctly orders the parts of an atom from heaviest to lightest in mass?
А
electron, proton, nucleus, neutron
В.
neutron, proton, nucleus, electron
С.
proton, neutron, electron, nucleus
D
nucleus, neutron, proton, electron

Answers

Answer:

nucleus, neutron, proton, electron

Explanation:

The list that correctly orders the parts of an atom from heaviest to lightest

in mass is as follows:

nucleus, neutron, proton, electron

The nucleus of an atom is composed of a tightly packed proton and

neutrons.

This makes the nucleus very dense and small. The nucleus are surrounded

by a negatively  charged electron.

The nucleus contribute to most of the weight of an atom.

This makes the nucleus the heaviest.

The neutron  is found in the nucleus of an atom. The neutrons are

electronically neutral.  The neutron are slightly heavier than proton.

Therefore, the neutron is the second heaviest part of an atom.

The proton is found in the nucleus of an atom. They a positively charged.

The proton is the third heaviest.

The electron revolves around the nucleus and are very light. In fact the

nucleus contributes to 99.9 % of the weight of an atom. This shows how

light the electrons are.

Therefore, the order from the heaviest to the lightest is as follows:

nucleus, neutron, proton, electron

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Which is the number of chromosomes in a haploid cell?

1n

2n

3n

4n

Answers

Answer:

Answer: Option A.

Explanation:

Haploid cell is the cell that have a single set of chromosomes . In human, haploid cells have 23 chromosomes compare to 46 number of chromosomes diploid cells have.

Answer: 23 chromosomes

Explanation:

Punnet square? Someone know who to do this

Answers

Answer:

Punnet squares are basically how you can somewhat "predict" the outcome of gene pools.

Explanation:

As you can see, the capital letters (RY) are dominant alleles meaning they will be the trait that shows no matter what. the lower case letters (ry) show recessive traits and will only show if paired with another recessive gene.

Genotype is the actual makeup so the letters. (Rr, Ry, ry... etc.)

Phenotype is the trait that shows such as brown hair, blue eyes, etc.

Frequency is just how many times the gene shows up and put as a fraction or percent.

write a short essay (not more than 5 sentence ) on how you think life began on earth​

Answers

Answer:

The earliest known life-forms are putative fossilized microorganisms, found in hydrothermal vent precipitates, that may have lived as early as 4.28 Gya (billion years ago), relatively soon after the oceans formed 4.41 Gya, and not long after the formation of the Earth 4.54 Gya.

Explanation:

in monohybrid cross between a pure breed plant that produces blue flowers (BB)and a pure breed plant that produces white flowers.The f1 generation produces only blue flowers. By means of a labelled cross diagram,state the type of flower you will expect if the f1 generation is self pollinated​

Answers

Answer: If the F1 generation is self-pollinated, 75% of the flowers will be blue, while 25% will be white.

Explanation:

Monohybrid cross between blue and white: BB x bbThe cross produces 100% Bb --> blue is dominant, so all the flowers will be blue. This is the F1 generation.If F1 is self-pollinated, it will be Bb x Bb.The cross will produce 25% BB, 50% Bb, and 25% bb.Since blue is dominant, 75% of the flowers will be blue, while 25% will be white.

Pictures:

The first picture is the BB x bb cross.The second picture is the Bb x Bb cross.I don't know why the pictures are appearing sideways. If you click the rotate button at the top right of the pictures, you can turn them.

why is forcing the cell to increase the rate of the cell cycle lead to error in DNA replication

Answers

We tend to think of the process of DNA replication as this well laid out stoic process like a factory line. It isn't. The DNA doesn't lie in a straight line for the DNA polymerase to read and it is moving - not static. It is tangled and curved. First understand this is the molecular level. Things don't "think", bacteria don't make decisions, they have no neurons. Everything is a chemical reaction that very often depends on osmotic pressure of one concentration being stronger then another both inside of the cell and outside. Nothing is empty though even at that level there is a lot of "nothing".


15. Which of the following are functions of the exoskeleton? Check all that
apply.

-Protection of internal organs
-Provide for muscle attachment and movement
-Structural support
-Prevention of water loss

Answers

Answer:

•Protection of internal organs

•Provide for muscle attachment and movement

•Structural support

The following that are functions of the exoskeleton are:

Protection of internal organsProvide for muscle attachment and movementStructural support

What is an exoskeleton?

An exoskeleton is an outer skeleton that is present outside the body of some insects and other organisms. The exoskeleton is made up of hard substances like calcium carbonate or chitin protein.

The exoskeleton protects the soft tissues and organs of organisms. They are helpful in saving the organism from predators and other factors of the environment.

The exoskeleton is present in most arthropods. They also help in reducing water loss from the body.

Thus, the functions of the exoskeleton are:

Protection of internal organsProvide for muscle attachment and movementStructural support

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what is the genetic causes of edward syndrome ​

Answers

Answer:

A baby with Edwards' syndrome has 3 copies of chromosome number 18 instead of 2. This affects the way the baby grows and develops. Having 3 copies of chromosome 18 usually happens by chance, because of a change in the sperm or egg before a baby is conceived.

Explanation:

DNA consists of ____ chains(s) of subuints, and RNA consists of _____ chain(s).

Answers

DNA consists of nucleotide chain(s) of subunits, and RNA consists of ribonucleotides

DNA has two chains of subunits and RNA has only one chain of subunits.

What are the differences between DNA and RNA?

DNA or Deoxyribonucleic acid is a nucleic acid structure. Its function is to work as an original blueprint or the basic code for protein synthesis. A DNA molecule has deoxyribose sugar, it has lost an oxygen molecule from the 3' carbon.

It also has phosphates and nitrogenous bases like adenine (A), guanine (G), cytosine (C) and thymine (T) in a unique sequence. These sequences form two chains which are intertwined to form a double helix.

Ribonucleic acid or RNA is also a nucleic acid. This directly takes part in protein synthesis. It is an important nucleotide and has nucleic acid in long chains that are present in all living cells. It has ribose sugar. It has the same nucleotides as DNA except for uracil (U) replaces thymine (T).

The main role of RNA is to act as a messenger. It gets instructions from DNA and uses them for controlling protein synthesis. This is present in a single chain.

Therefore, DNA has two chains of subunits and RNA has only one chain of subunits.

Read more about nucleic acids, here

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This species of squirrel has been separated by the Grand
Canyon. Which term best describes the differences
between them?
) Variation
O b) Extinction
Population
d) Overpopulation
Hurry I have 10 minutes left pls

Answers

Answer:

Explanation:b

What is the role that genes play in making proteins?

I need answers like asap plz help

Answers

The general portions!

loop of Henle concentration gradient

Answers

Answer:

The Loop of Henle serves to create a concentration gradient throughout the nephron which helps increase the reabsorption of water and certain ions. In the thin descending limb, water is very permeable and is reabsorbed due to the existing concentration gradient in the medulla.

Can you help me please

Answers

Answer:

what is the question?  please give more details

Explanation:

ignore how i selected them) PLEASE HELP ME. DO IT CORRECTLY PLEASEEEEEEE

Answers

They both look correct........the first is GG which means it’ll be green and the second is Gg which means it could end up being either color therefore you can’t determine the color
I think they are both green

What is the benefit of
starting with two coples
of each chromosome in
Interphase I?

Answers

Answer:

Here u go sorry if wrong, if right u welcome ;)

The S phase of a cell cycle occurs during interphase, before mitosis or meiosis, and is responsible for the synthesis or replication of DNA. In this way, the genetic material of a cell is doubled before it enters mitosis or meiosis, allowing there to be enough DNA to be split into daughter cells

Which two major parts of the Earth system does this photo most cieery
show?

A. Geosphere
B. Cryosphere
C. Atmosphere
D. Biosphere

Answers

Answer:

I'd say that your answers are A) and B).

list 5 characteristics that genes code for.

Answers

Degeneracy, nonoverlapping, commaless, universality, and polarity.

Example of decomposer

Answers

Answer:

mushrooms are decomposers!

Answer:

Earth worms are a example or works in general

Basic needs. Living things have basic needs in order to survive. Plants and animals have like needs. How they use the things required for life can be a little different. Can you drag these phrases to the correct column?

Answers

Answer:

is bvasic living thing ok so obiously the answaer is c because it always is ((((((((((((((((answer c)))))))))))))))))))))))

ok so the looooongest word that most people kno is . but thats actually not that long to some people that kno long words so here is the longezt word in the wold, supenemendeddentenilisitationsentinalizinilitioninitialalizedcaliflagiliciousinitialdistintialidocioloassociationlationsensationinitiliationilitisintialidocious. so theres your answer ok an extremly long word for your game (use ok) accountiticationmicjationmasonyaynitiationpronoutiationnaysonnitiationassociationassistiation is still normal length you could say its used commonly around the world and in sentences/essays/paragraphs

Explanation:

A positive control is a sample in an experiment that produces a known result to compare with the test sample after the same treatment. It is used to control for unknown variables and confirms that all your reagents work.
In this case, the positive control is a cell line expressing wild-type CCR5.
Which of the following do you think will be a good positive control for this experiment?
a) T Cell Helper Line
b) Macrophage cell line without CD4
c) Unedited wild type macrophage
d) Edited macrophage

Answers

Explanation:

Human immunodeficiency virus type 1 (HIV-1) enters target cells by first binding to the primary receptor CD4 and then to a coreceptor, generally one of the chemokine receptors CCR5 and CXCR4 (4). CD4 binding induces structural changes in the envelope (Env) glycoprotein that form and expose the coreceptor binding site. There are two main interactions between Env and coreceptor (13, 14, 25, 50, 51): the base of the third variable loop (V3) engages the N terminus of the coreceptor, while the crown of the V3 loop that includes the highly conserved GPGR/Q arch motif binds to the extracellular loops of the coreceptor, with the second extracellular loop of the coreceptor being particularly important (16, 25, 35, 48, 62). Although some HIV-1 strains are able to use a variety of different G protein-coupled receptors to gain entry into CD4+ cell lines, the great majority of these viruses use CCR5 and/or CXCR4 as coreceptors to infect primary cells (3, 4, 10, 23, 47, 66). CCR3, GPR15, APJ, and FPRL-1 are among the most frequently used alternative coreceptors when overexpressed on cell lines (11, 26, 43, 47, 57). Rare cases of HIV-1 strains that are able to use FPRL-1 and GPR1, but not CCR5 or CXCR4, have been reported (57); however, their in vivo relevance remains unknown.

To characterize the biological processes underlying HIV/simian immunodeficiency virus (SIV) transmission, we recently developed an experimental strategy that permits the identification, enumeration, and molecular cloning of transmitted/founder (T/F) viruses (28, 53). This strategy, which employs single-genome amplification (SGA) and direct amplicon sequencing of HIV/SIV RNA or DNA from the plasma or infected cells, makes it possible to infer the nucleotide sequence of the viral strain(s) that initiated productive infection weeks earlier (1, 28, 29, 37, 53, 58, 67). An important prediction of this approach has been that inferred T/F viruses are fully functional and encode all proteins necessary to establish a new infection. Indeed, this prediction has been borne out in numerous studies, which have shown that T/F viral genes as well as full-length genomes are biologically active. Sets of T/F Envs have been shown to mediate efficient virus entry in single-round infection assays, and they invariably use CCR5 as a coreceptor (28, 34). Similarly, T/F infectious molecular clones (IMCs) of HIV-1, SIVmac and SIVagm all produce replication competent virus that grow to high titers in primary CD4+ T cells (22, 38, 54).

MATERIALS AND METHODS

Amplification of the HIV-1 env gene. Serial plasma samples collected from an acutely infected plasma donor, ZP6248, were purchased from ZeptoMetrix. A total of seven plasma samples were collected between 12 February and 9 March 1997, and viral loads (VLs) were determined by the COBAS Amplicor HIV-1 monitor test.

Sequence analysis. All SGA amplicons were sequenced directly by cycle sequencing and dye terminator methods using an ABI 3730xl genetic analyzer (Applied Biosystems, Foster City, CA). Individual sequences were assembled and edited using the Sequencher program 4.7 (Gene Codes, Ann Arbor, MI). The env sequences were aligned using CLUSTAL W (60), and manual adjustment for optimal alignment was done using MASE (20).

when would a forest be sustainable?

Answers

Answer:  B: When supply is greater than demand

Explanation:Hope this helps

23. What is MOST likely TRUE about forensic scientists?
A
They have to follow the rules of the judicial system.
B
Most are biologists who decided to study forensics.

C
They are not permitted to use hazardous materials.
D
Many of them become certified immediately after high school.

Answers

Answer:

d

Explanation:

many of them become certified

Answer:

They have to follow the rules of the judicial system.

but if not i believe it might be b :) hope this helps!

Explanation:

I will give a Brainlyist.

Which statements are true about
ribosomes?
.They are membrane bound
.They make proteins
.They can float free or be connected to Rough
.Endoplasmic Reticulum

Answers

Answer:

They make proteins, They can float free or be connected to endoplasmic reticulum

ah the person above had the answer! hope you have a good day!

How are living things put together?

Answers

Answer:

All living things are made of cells; the cell itself is the smallest fundamental unit of structure and function in living organisms. In larger organisms, cells combine to make tissues, which are groups of similar cells carrying out similar or related functions.

Explanation:

Which solution is more diluted? Solution 1:
1000 mL of water
60g of salt
Solution 2:
500 ml of water 60 g of salt

A.Solution 1
B.Solution 2
C.Both solutions have the same concentration​

Answers

Answer:

the answer is A: solution 1.

Explanation:

You are trying to help a friend sort some specimens in her lab. She collected organisms from a lake and forgot to label the sample with the part of the lake from which they were taken. Please select the item below that is correctly matched with its collection zone.
a. periphyton labeled "open water"
b. phytoplankton labeled "littoral zone"
c. anaerobic bacteria labeled "limnetic zone"
d. zooplankton labeled "limnetic zone"
e. cattails (emergent plants) labeled "profundal zone"

Answers

Answer:

D. zooplankton labeled "limnetic zone"

Explanation:

the zone called the limnetic zone is a well lighted and open zone in a body of fresh water such as the lake or the pond. this zone has the plankton in dominance. both the phytoplankton and the zooplankton. plankton play an important role in the food chain.

zooplankton are primary consumers in this limnetic zone. zooplankton consists of rotifers and copecod

Osmosis is the movement of _____________________ from an area of high concentration to low concentration

A) salt
B)water
C)sodium
D) sugar

Answers

Answer:

B) Water

Explanation:

Osmosis is the movement of water from an area of high concentration to an area of low concentration across a semi permeable membrane

how do people tend to use land as the human population increases?

Answers

Answer:

C

Explanation:

As more humans are increasing we need food

One strand of DNA nucleotides is read as 5' - GCATATTG - 3'. What would
be the complementary strand?

Answers

Answer:

The correct answer would be: 3' - CGTATAAC - 5'

Explanation:

DNA molecule is a double-stranded molecule structure that has two distinct nucleotide chains joined together with hydrogen bonds between the nitrogenous bases of each strand. Adenine binds with thymine and cytosine binds with guanine by hydrogen bonds always in complementary strands.

These strands are complementary to one another as they have complementary bases in the complementary strand of one nucleotide chain of DNA. So,

5' - GCATATTG - 3' - DNA nucleotide of one strand

3' - CGTATAAC - 5' complementary strand

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