Similarity is judged by comparing the primary and secondary analogues’ ___________, that is, how connected/relevant they are to each other.

Answers

Answer 1

Similarity is judged by comparing the primary and secondary analogues’ relevance or how connected they are to each other.

What is a secondary analogue?

An analogue is a term used to describe substances that have a similar structure to another substance. A secondary analogue is a structural analogue of a drug that is similar to the original compound but has a different molecular structure, different physical and chemical properties, and therefore different pharmacokinetic and pharmacodynamic profiles. It is a compound that has been designed to mimic the original compound and offer similar pharmacological activity, with the aim of improving the therapeutic effects of the original drug.

Additionally, a secondary analogue could be developed to eliminate or reduce the side effects of the primary analogue. For instance, the primary analogue could cause liver toxicity while the secondary analogue is designed to eliminate that risk or reduce its incidence.A comparison of primary and secondary analogues is often done to determine the relevance and connectivity of the two substances. This analysis is usually done by chemists and pharmacologists. The primary analogue is the original compound while the secondary analogue is a structurally similar compound that has been designed to improve the properties of the primary analogue. If the secondary analogue offers similar pharmacological activity as the primary analogue, with little or no side effects, then it is considered to be a better therapeutic option.

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Related Questions

Is Ratification of the Constitution endangers state's rights Federalists or
Anti-federalists?

Answers

the correct answer is federalists

The purpose of this exercise is to compare the variability of xy and with the variability of (x4 – x2). Complete parts a through e below. --- a Suppose the first sample is selected from a population with mean 14 = 135 and variance of = 576. Within what range should the sample mean vary about 95% of the time in repeated samples of 64 measurements from this distribution? That is, construct an interval extending 2 standard deviations of Xy on each side of The interval is (10) (Simplify your answers. Type integers or decimals. Do not round.)

Answers

In repeated samples of 64 measurements from this distribution, the sample mean should fluctuate between (129.12 and 140.88) around 95% of the time.

We must compute the sample mean's standard deviation in order to establish the range within which the sample mean should fluctuate around 95% of the time in repeated samples of 64 observations from a population with a mean of 135 and a variance of 576.

The standard error, sometimes referred to as the standard deviation of the sample mean, is calculated using the following formula: Standard Error = (Standard Deviation of the Population) / sqrt(Sample Size).

In this case, the standard deviation of the population (xy) is the square root of the variance, which is sqrt(576) = 24. The sample size is 64. Plugging these values into the formula:

Standard Error = 24 / sqrt(64) = 24 / 8 = 3

The standard error represents the average amount of variability we expect in the sample mean. To construct a 95% confidence interval, we need to consider the critical value associated with a 95% confidence level. For a normal distribution, this critical value is approximately 1.96.

When the standard error is multiplied by the critical value, we obtain:

Margin of Error = Standard Error * Critical Value = 3 * 1.96 = 5.88

Now, we can construct the confidence interval by subtracting and adding the margin of error from the population mean:

Confidence Interval = (Population Mean - Margin of Error, Population Mean + Margin of Error)

Confidence Interval = (135 - 5.88, 135 + 5.88)

Simplifying the interval, we have:

Confidence Interval = (129.12, 140.88)

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please help!!!

when is election day?

A. the first tuesday following the first monday in november

B. the first tuesday in november, whenever it falls

C. the first tuesday in november, unless it is november 1st

D. the first tuesday in november, unless it is november 2nd

Answers

Answer:

the other person saying it's a link is a scam do not believe them

Ancient Greeks lived answer quick plzz

Answers

Answer:

What is the radius and diameter of the following circle?

Explanation:

What is the radius and diameter of tje following circle?

ways in which employment can minimize emotional stress​

Answers

Answer:

Proper management training.

Conflict resolution.

Teamwork.

Stress management.

Set expectations.

Time off.

Mental health.

Corporate wellness.

Explanation:

(hope this helps)

in terms of maslow’s hierarchy of need, families living in poverty may be focused more on which type of needs rather than self-actualization?

Answers

Maslow's Hierarchy of Needs is a motivational theory that consists of a five-tier model of human needs, often depicted as hierarchical levels within a pyramid, the concept is that human beings have five basic needs, and these needs must be satisfied in a specific sequence: physiological, safety, love/belonging, esteem, and self-actualization.

These five levels of needs make up the structure of the hierarchy of needs.In terms of Maslow's hierarchy of needs, families living in poverty are more focused on physiological and safety needs. They prioritize satisfying their basic needs such as food, shelter, clothing, and other physiological needs to meet their basic survival needs. Poverty affects families' physiological needs by exposing them to adverse health effects that arise from inadequate nutrition, poor sanitation, and unsafe housing conditions.

Poverty can also affect their safety needs, which include the need to feel secure and safe from harm. Families living in poverty may experience frequent exposure to violence, crime, and environmental hazards which create an unsafe and unstable environment that affects their safety needs.In conclusion, families living in poverty tend to focus more on satisfying their physiological and safety needs than self-actualization. Satisfying the basic needs is essential for survival and gives them the confidence to pursue their aspirations and goals.

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Investigators are examining some evidence from a crime scene. They learn that the victim was wearing a blue shirt when she was killed. A pane of glass in the front
door was broken. The victim owned a golden retriever. The victim had a friend named Maria. Which of these facts is most relevant to the crime?
O Blue shirt
O Pane of glass
O Golden retriever
Friend named Maria

Answers

Answer: Pane of glass

Explanation:

Julie, a social robot, is expected to provide assistive care to those in a residential care facility. Using a functionalist approach, this best qualifies as which of the following? a. Manifest dysfunction b. Latent function c. Manifest function d. Latent dysfunction

Answers

The functionalist approach can be applied to the analysis of Julie's role as a social robot in providing assistive care to those in a residential care facility. According to the functionalist approach, social structures serve a purpose in society, and social institutions are developed to meet the needs of people.

In this regard, the concept of manifest and latent functions and dysfunction can be used to analyze Julie's role. Manifest functions refer to the intended and overtly stated functions of a social structure or institution, while latent functions refer to the unintended or covert functions that it serves. Manifest dysfunctions refer to the negative consequences that are intended or overtly stated, while latent dysfunctions are unintended or covert negative consequences.

In Julie's case, her role as a social robot providing assistive care to those in a residential care facility can be best described as a manifest function. This is because the use of social robots like Julie is intended to help the elderly or people with disabilities live more independently and to provide support and assistance in performing daily activities, including bathing, dressing, and taking medication. Moreover, Julie's role is directly related to the purpose of the residential care facility, which is to provide care and support to those in need.

As such, the use of social robots like Julie can be considered a manifest function of the residential care facility, as it directly serves its intended purpose. Therefore, the answer to the question is manifest function.

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whats the answer ill give brainliest

Answers

i believe it's all of the above

Answer:

3rd

Explanation:

beccause it came after

Which of the following best describes a government that is run by a tyrant who has seized power with the help of the military?
1. A monarchy.
2. An indirect democracy.
3. A dictatorship.
4. A oligarchy.

Answers

I believe the answer is 3
3, a dictatorship. That’s another way of saying a tyranny.

In which stage of the butterfly's life cycle do most of the changes of metamorphosis
happen?
A. Pupa
B. Adult
O C. Larva
Plz help

Answers

Answer:

pupa

Explanation:

because thats when it is in the cocoon?

Answer: A. Pupa

Explanation:

:)

Help me pls fasttttttt​

Answers

don’t use the link. those are scams

Longitudinal studies are useful for addressing which criterion used for establishing causality?
a. correlation
b. time order
c. complete causation
d. nonspuriousness

Answers

Longitudinal studies are useful for addressing the criterion of time order used for establishing causality. The correct answer is option(b).

A longitudinal study is a kind of research in which data is gathered for the same subjects repeatedly over an extended period of time. A longitudinal study can last anywhere from several weeks to decades. Longitudinal studies are usually conducted to look for causality. A criterion is a set of rules or standards that are used to assess or judge something. Causality is the relation between an event (the cause) and a second event (the effect) in which the second event is regarded as a direct consequence of the first.

The criterion of time order is used to establish causality, which is why longitudinal studies are beneficial in this regard. In a longitudinal study, the same group of subjects is tested several times over an extended period of time. This allows the researchers to see how the subjects alter over time. They can also examine how a specific event may have caused a change in a subject over time. Thus, it helps in establishing the criterion of time order used for establishing causality. Therefore, the correct answer is option B.

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the soccer team is transitioning from off-season to preseason training. how should the team's resistance training frequency be altered?

Answers

As the soccer team is transitioning from off-season to preseason training, the team's resistance training frequency should be altered in the following ways: During off-season training, resistance training frequency should be high.

This will allow the athletes to build a solid base of strength that will be essential during the competitive season.However, when transitioning from the off-season to the pre-season, resistance training frequency should be reduced. This will help the athletes to recover from the intense off-season training and to transition to the upcoming season with a fresh mindset. As the pre-season training period progresses, resistance training frequency can be increased to prepare the athletes for the upcoming competitive season. It's also important to note that the intensity and duration of resistance training sessions should be altered in conjunction with changes in frequency to optimize the team's training program.

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i
need it ASAP


Explain logical reasoning
And show how (3 ways) it is critical to our everyday
life.

Answers

Logical reasoning is a cognitive process that involves using rational thinking, evidence, and logical principles to reach conclusions or make decisions.

It is critical to our everyday lives in various ways. Firstly, logical reasoning is essential for effective decision-making. By employing logical thinking, individuals can assess information, evaluate options, consider potential outcomes, and make informed choices based on sound reasoning. This helps in avoiding impulsive decisions and increases the likelihood of achieving desired outcomes. Secondly, logical reasoning is vital for problem-solving. It enables individuals to break down complex problems into manageable parts, analyze the underlying causes, and develop logical solutions. By applying logical thinking, individuals can identify patterns, evaluate evidence, and generate strategies to overcome challenges. Logical reasoning promotes systematic thinking, ensuring that problems are approached in a methodical and structured manner. Lastly, logical reasoning is closely tied to critical thinking. It allows individuals to evaluate arguments, detect fallacies, and identify inconsistencies in reasoning. By logical thinking, individuals can analyze information objectively, separate facts from opinions, and engage in meaningful discussions. This enhances their ability to think critically, question assumptions, and arrive at well-reasoned conclusions.

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Question 11

1 pts

What effect did George Washington's 1776 reading of Thomas Paine's words have on the upcoming

mission across the Delaware?

o The men were inspired by the words and continued their mission, despite hardships.

The men were discouraged by the words and abandoned their missions

O Washington became too emotional to continue the mission after sharing the words.

O The men who heard these words decided to desert the Continental Army'll

Question 12

Answers

The correct answer is A) The men were inspired by the words and continued their mission, despite hardships.

The effect that George Washington's 1776 reading of Thomas Paine's words had on the upcoming mission across Delaware was that the men were inspired by the words and continued their mission, despite hardships.

Thomas Paine was a good writer and had a Patriotic sense that served to inspire the troops of the Continental Army when it was most needed. That is why General George Washington, leader of the Continental Army, dedicated to reading Thomas Pain's writings.

Thomas Paine was the author of pamphlets such as "Common Sense," or "The American Crisis," documents that offered arguments to support the American troops in the Revolutionary War and clarified the reasons for going into war against the British troops.

mrs. pollak fell on a busy city sidewalk and broke her leg. although hundreds of pedestrians saw her lying on the ground, most failed to recognize that she was in need of medical assistance. their oversight best illustrates one of the dynamics involved in a. the bystander effect. b. the self-fulfilling prophecy. c. the mere exposure effect. d. the reciprocity norm.

Answers

The dynamic involved in Mrs. Pollak's situation, where most pedestrians failed to recognize her need for medical assistance despite witnessing her fall, is best illustrated by the bystander effect. The option A is correct answer.

The bystander effect refers to the phenomenon where individuals are less likely to help a person in need when there are other people present. In this case, the large number of pedestrians on the busy city sidewalk created a diffusion of responsibility, leading to a decreased likelihood of anyone taking action to help Mrs. Pollak.

Each bystander may have assumed that someone else would intervene or may have looked to others for cues on how to respond. The presence of many witnesses in this situation can lead to a diffusion of responsibility, as individuals may feel less personally accountable for taking action.

This diffusion can result in a collective inaction or failure to recognize the urgency of the situation, as seen in the pedestrians' oversight in recognizing Mrs. Pollak's need for medical assistance. Understanding the bystander effect is crucial for promoting a more helpful and compassionate society.

By raising awareness about this phenomenon, individuals can be encouraged to overcome the diffusion of responsibility and take action in situations where assistance is needed.

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some tips for university? I

Answers

Answer:

learn how to budget brotha

Explanation:

Nutria were brought to the United States for their fur. When some of them escaped into the wild, they started eating the grasses and shrubs in their new environment. These shrubs were essential for preventing soil erosion. In this scenario, how was this invasive species introduced to the new environment?

Answers

Invasive species are not native to the area and can harm the ecosystem. The nutria, a rodent that eats grass and shrubs and is native to South America, was introduced to the United States for its fur. When some escaped into the wild, they began to eat the grasses and shrubs in their new habitat.

These plants were critical for preventing soil erosion. The nutria were brought to the United States for their fur. Some of them were accidentally released into the wild, and they began to eat the grasses and shrubs in their new environment. Invasive species are animals or plants that are not native to the area and can harm the ecosystem. The nutria is one such animal. It is a rodent that is native to South America and is known for eating grasses and shrubs.

Because of its fur, it was introduced to the United States. How were nutria introduced to the new environment? Some nutria escaped from fur farms and made their way into the wild. They began to eat the grasses and shrubs in their new environment. These plants were critical for preventing soil erosion, and their destruction had far-reaching consequences. The nutria was able to reproduce and thrive in the wild due to the absence of natural predators. As a result, it became a major problem and is now considered an invasive species. The presence of nutria in the United States has resulted in significant economic losses. They have destroyed wetlands, caused soil erosion, and damaged crops. In response to this problem, several states have implemented nutria control programs to reduce their population. Invasive species like the nutria are a major threat to the environment and the economy. They are typically introduced to new environments due to human activities like trade, travel, and the pet industry. Once they escape into the wild, they can cause significant damage to the ecosystem. The nutria, a rodent that eats grass and shrubs, was introduced to the United States for its fur. When some escaped into the wild, they began to eat the grasses and shrubs in their new habitat. These plants were critical for preventing soil erosion. The nutria was able to reproduce and thrive in the wild due to the absence of natural predators. As a result, it became a major problem and is now considered an invasive species.

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according to aristotle, how does one achieve a virtuous life?

Answers

According to Aristotle, an individual can achieve a virtuous life by developing good habits through consistent practice and self-discipline. He believed that virtue is not innate, but rather a skill that can be developed over time.

According to Aristotle, virtue is the middle ground between two extremes. For example, courage is the middle ground between cowardice (deficiency) and recklessness (excess). Virtue is a habit that is developed by consistently choosing to act virtuously in a particular situation. For example, a person who consistently chooses to act courageously when faced with a difficult situation will eventually develop the habit of courage and become a courageous person.

Aristotle believed that in order to achieve a virtuous life, an individual must develop good habits through consistent practice and self-discipline. He believed that virtue is not innate, but rather a skill that can be developed over time. He argued that there are two types of virtues: moral and intellectual. Moral virtues are developed through consistent practice and self-discipline. They include courage, justice, generosity, and self-control. Intellectual virtues, on the other hand, are developed through education and include wisdom, understanding, and practical skills. Both moral and intellectual virtues are necessary to achieve a virtuous life, but moral virtues are more important because they are directly related to an individual's character. According to Aristotle, an individual who consistently practices moral virtues will develop a virtuous character, which will lead to a virtuous life.

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select the two most important elements of the psychiatric interview to establish a mental illness diagnosis.

Answers

The two most important elements of the psychiatric interview to establish a mental illness diagnosis are A. Psychiatric History and C. mental status examination.

What should one look for in a psychiatric interview?

The Psychiatric history is a detailed account of the patient's symptoms, including their onset, duration, severity, and course. The psychiatrist will also ask about the patient's medical history, family history, and social history.

The mental status examination is a systematic assessment of the patient's appearance, behavior, mood, thinking, and memory. The psychiatrist will observe the patient's appearance and behavior, and will ask questions about the patient's mood, thinking, and memory.

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The full question is:

Select the two most important elements of the psychiatric interview to establish a mental illness diagnosis.

A . Psychiatric history

B . Family history

C . Mental status examination

D . Review of system

help ASAP please ill mark brainliest

Answers

Answer:

D! ( sorry for answering so late!)

Explanation:

In which of the following situations would a contract most likely NOT be terminated? a schoolteacher lets her teaching license lapse
a horse owner who contracts with a farmer suddenly has ethical questions about the practice
a man adjudged mentally insane cannot perform his job as contracted
a family that contracts with a daycare for daily childcare files for bankruptcy

Answers

A contract most likely NOT be terminated if A horse owner who contracts with a farmer suddenly has ethical questions about the practice. (Option 2)

A contract is most likely not terminated in a situation where a horse owner who contracts with a farmer suddenly has ethical questions about the practice. Ethical concerns or personal moral dilemmas generally do not provide sufficient grounds for contract termination. Contracts are legally binding agreements that are enforceable based on the agreed-upon terms and conditions.

Ethical concerns, while important, are subjective and not typically recognized as valid reasons for contract termination under the legal framework. Unless there are specific provisions in the contract that address ethical considerations or provide an option for termination based on moral objections, the contract is expected to be upheld regardless of the individual's ethical concerns.

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Complete Question:

In which of the following situations would a contract most likely NOT be terminated?

a schoolteacher lets her teaching license lapsea horse owner who contracts with a farmer suddenly has ethical questions about the practicea man adjudged mentally insane cannot perform his job as contracteda family that contracts with a daycare for daily childcare files for bankruptcy

Explain the economic impact of Italy’s location and trade on Renaissance art and culture.

please help me with this problem i am stuck like chuck

Answers

Answer:

A improved banking system, provided financial security for major transactions. Expanded trade routes, that reached far to the East. As people lived closer, they began to spread the word to make art and culture available to more, and experiencing a huge change in culture.

Hope this helped ❤️

answer this correctly please

Answers

DON'T OPEN THE LINK ITS A VIRUS!!!

the earliest civilization currently identified in mesoamerica is known as the_______

Answers

The earliest civilization currently identified in Mesoamerica is known as the Olmec civilization. The Olmec civilization emerged around 1200 BCE and was located in what is now modern-day Mexico.

They are considered one of the earliest complex societies in Mesoamerica and exerted a significant influence on later cultures in the region. The Olmec people are known for their distinctive artistic style, particularly their monumental stone heads, as well as their agricultural practices and trade networks. They developed sophisticated systems of governance and religious beliefs, laying the foundation for future civilizations in Mesoamerica, such as the Maya and Aztec civilizations.

The Olmec civilization thrived for several centuries before declining and eventually disappearing, leaving behind a lasting legacy in Mesoamerican history.

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why do you think the obama administration pursued a trade deal with korea in 2012

Answers

The Obama administration pursued a trade deal with Korea in 2012 to enhance the American economy and strengthen the trade relationship between the two countries.

The main objective of this deal was to reduce tariffs, boost exports and create job opportunities.The agreement aimed at eliminating 95 percent of tariffs on goods between the United States and South Korea. This led to the establishment of a stable, predictable, and transparent trading relationship between the two countries, which resulted in expanding the economy and generating new job opportunities.

For the United States, South Korea is the sixth-largest trading partner, and the trading relationship is estimated to be worth over $100 billion. The trade agreement helped reduce barriers to investment and facilitated trade between the two countries.

American farmers and manufacturers benefitted significantly from this agreement, which boosted their exports. Additionally, the deal strengthened America's presence in Asia by strengthening relationships with its allies and demonstrating America's commitment to the region.

In conclusion, the trade deal with South Korea was a vital step for the Obama administration towards expanding the US economy, creating jobs, and boosting American exports.

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What happens when societies do not have governments?
1. There is chaos among the citizens.
2. Large scaled projects such as road and bridges get completed.
3. Families and tribes live separated from one another.
4. There is peace within a social group.

Answers

Answer:

1

Nothing to keep the society in place

Answer: i would say 1

Explanation:

We can rule 4 out first and 2 can follow. While yes 3 will happen it wont be as important as 1

What does the following diagram show? Write your views on this matter. (5 marks)

Answers

This diagram shows equality between male and female. I agree with this image because i believe strongly in equality.

PLEASE SOMEONE HELP URGENT!!
South Africa has invested heavily in improving rail systems and expanding sea ports. There has been an increase in the GDP of this country because of the investment made in which of the following?
A. Infrastructure
B. Human Capital
C. Entrepreneurship
D. Natural Resources

Answers

Answer:

C) Entrepreneurship

Explanation:

I may be wrong but this is the most logical answer to me.

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Shane and Abha earned a team badge that required their team to collect no less than 2000 cans for recycling. Abha collected 178more cans than Shane did.Write an inequality to determine the number of cans, S, that Shane could have collected. Please help ASAP Which of these is NOT an example of an environmental factor that can affect an organism's growth?Inheriting the gene for purple flower petals orLimited or no shelter/space to nurture offspring orinadequate sunlight orinsufficient access to water or nutrients What interest rate, compounded monthly, is equivalent to 10.04% effective interest rate? True/False: let a be square real matrix if v is an eigenvector for eigenvalue then v is an eigenvector for eigenvalue HELP ME!!! a soldier who serves for pay in a foreign army What did Bessie Coleman's father do for a living? Below is the graph of a trigonometric function. It has a maximum point at (-5, 2.5) and a minimum point at(-1.7, -4.5). you are completing a network installation as part of a team. another group has cabled wall ports to a patch panel. is any additional infrastructure required? Please, help me!!Question is down below.. xyz insurance company gives direct authority to its producers to sell insurance through an agency contract, but nothing is stated regarding the collection of premiums. which authority grants the producer the right to collect premiums? 4 NH3 + 3022N2 + 6HO2.) a) A chemist burned 0.25 moles of ammonia gas (NH,) in the presence of excess oxygenpps to produce 2.95 grams of nitrogen gas (N2). Calculate the theoretical yield ofnitrogen gas. What is the name of the building above? Five more then six times a number is 17.what is the number Sonnet 43by Elizabeth Barret BrowningHow do I love thee? Let me count the ways.I love thee to the depth and breadth and heightMy soul can reach, when feeling out of sightFor the ends of Being and ideal Grace.I love thee to the level of everyday'sMost quiet need, by sun and candlelight.I love thee freely, as men strive for Right;I love thee purely, as they turn from Praise.I love thee with the passion put to useIn my old griefs, and with my childhood's faith.I love thee with a love I seemed to loseWith my lost saints,I love thee with the breath,Smiles, tears, of all my life!and, if God choose,I shall but love thee better after death.write about your own personal reaction (emotional response) to the poem. try to explain how you approached the poem and how your opinion could shape or change its meaning. A nurse is testing a client for conduction deafness by performing the weber's test. Which of the following actions should the nurse take when performing this test? A: place the base of the vibrating tuning fork on the client's mastoid process b:count how many seconds a client can hear a turning fork after it has been struck c: place the base of a vibrating turning fork on the top of the client's head d: move a vibrating turning fork in front of the client's ear canals one after the other which of the following circumstances most likely would cause an auditor to consider whether material In mice, agouti coloration (A) is a dominant trait for fur color over black fur(aA Punnett square diagram is provided. A particular generation ofoffspring has a ratio of three agouti individuals to one black individual.Which of the following genotype combinations is possible for the parentA: aa x aa B: AA x Ar C:Aa x AaD: AA x AA HELP ME PLEASE! Solve for the value of a. 1. The daily demand for a popular CD in a music store is approximately M200, 20). The cost of keeping the CD on the shelves is 5.04 per disc per day. It costs the store $100 to place a new order. There is a 7-day lead time for delivery. Determine the store's optimal inventory policy given that the store wishes to limit the probability of shortage to at most.02. 2. The daily demand for camera films at a gift shop is N300, 5). The cost of holding a roll in the shop is 5.02 per day, and the fixed cost of placing a replenishment order is $30. The shop's inventory policy is to order 150 rolls whenever the inventory level drops to 80 units. It simultaneously maintains a buffer of 20 rolls at all times. a. (a) Determine the probability of running out of stock. b. (b) Given the data of the situation, recommend an inventory policy for the shop given that the shortage probability cannot exceed What country dominated Ireland in the 1800s?(1) Great Britain(2) The United States(3) Russia(4) Japan(HELP PLS ASAP)