Stimulation of the insulin receptor by ligand binding and autophosphorylation eventually leads to the activation of glycogen synthase and the translocation of glucose transporters to the plasma membrane. One strategy for treating diabetes is to develop drugs that act as inhibitors of the phosphatase enzymes that remove phosphate groups from the phosphorylated tyrosines on the insulin receptor. Why might this be an effective treatment for diabetes

Answers

Answer 1
By inhibiting the phosphates enzymes, the results of signal transduction will be maintained, even when insulin binding has ceased. The tyrosine of the insulin receptor will remain phosphorylated allowing for continued activation of PDK1, which will continue to phosphorylated and activate protein kinases. These protein kinases will phosphorylation and deactivate glycogen synthase kinase, allowing for continued activation of glycogen synthase. Inhibition of the phosphorylase will also allow continued translocation of glucose transporters to the plasma membrane through the continued activation of protein kinases. These responses will be allowed to occur continuously following a single binding of insulin. This would be an effective treatment for diabetes because it will amplify the cellular response to insulin.

Related Questions

Fill in the blank on this paper

Answers

Answer:

1. accelerating

2. 0 to 10 m/s

3. constant speed

4. decelerating

5. 10 m/s to rest

6. at rest

7. stopped

8. accelerating

9. increasing

Most cells spend most of their life in:
A. interphase

B. cytokinesis

Answers

Answer: Interphase

Explanation:

Answer:

A. Interphase

Explanation:

I hope this help ;)

The diagram below represents some changes that took place in a bacterial population recently exposed to an antibiotic.Which statement would best explain the presence of bacteria on day 4?A) A bacterial population cannot survive exposure to antibiotics.B) This bacterial population cannot survive exposure to this antibiotic.C) Bacteria can change whenever it is necessary to survive antibiotic treatment.D) Some of the bacterial population was resistant to this antibiotic.

Answers

About the question:

You will find the diagram used to answer the question in the attached files.

Answer:

D) Some of the bacterial population was resistant to this antibiotic.

Explanation:

The term resistance refers to an inheritable change in a population sensitivity, reflected through the consecutive failure of the chemical effects, correctly used to reach a desired effect on the target population.

The excessive use of antibiotics on the bacteria population leads to the fixation of new mutated genes -by natural selection-. The mutated genes make these cells even more resistant to the drug.

In the exposed example we have,

Day 1 ⇒ a big population of white bacteria and only one black cell, probably carrying mutated genetic material.

The population was treated with antibiotics.

Day 2 ⇒ there are fewer white bacteria and three black cells. This means that white bacteria are dying, while the black ones are reproducing.

The mutated phenotype gets to survive under the effects of the chemical.

Day 3 ⇒ There are no more white bacteria. Only the black population survived and keeps reproducing.

The mutated bacteria reproduce with the capability of tolerating the antibiotic dose that is usually used to destroy a population of white bacteria.

Day 4Black bacteria got to survive a produce a big population. Remember that bacteria follow the exponential growth model, meaning that their reproductive rate is too high. This black population survived the antibiotic action and reproduced at high rates.

Help please someone please what is the answer

Answers

answer:
false

explanation:
acid rain is not acid precipitation
acid rain contains acidic substances which are dispersed into the atmosphere
while acid precipitation involves sleet, snow, fog and cloud vapor
acid rain is limited to a period of a year but acid precipitation happens all year
but it does cause chemical pollution due to the sulfur dioxide and nitrogen oxides are released in the air.
Answer: False


Explanation: falseeeeee


WILL GIVE BRAINLIEST IM ON A TIMER!!! A student completed a lab report. Which correctly describes the difference between the “Question” and “Hypothesis” sections of her report? “Question” states what she is asking, and “Hypothesis” states the result of her experiment. “Question” states what she is asking, and “Hypothesis” states what she thinks the answer to that question is in “if . . . then . . . because” format. “Question” describes what she is trying to find out, and "Hypothesis" states the procedures and methods of data collection. “Question” describes what she is trying to find out, and “Hypothesis” states any additional information or prior knowledge about the question.

Answers

“Question” states what she is asking, and “Hypothesis” states what she thinks the answer to that question is in “if . . . then . . . because” format.

hii! i’ll give brainliest pls help

Answers

Answer:

Landslide!

Explanation:

Since the house is build on a hill there is the possiblitie that the house will fall so it has to be landslide. The trees will help the house stay put.

I hope this helped!!

Guard cells
2 points
1. Series of reactions in which a molecule of glucose is broken down.
2. Stomata are flanked by them, and they swell or shrink by taking in or losing water.
3. Process that doesn't need oxygen.
4. Plant capable of synthesizing its own food from simple organic substances.

Answers

2) Stomata are flanked by them...

Transpiration is controlled by opening and closing of the stomata, which is accomplished through swelling or shrinking of guard cells.

A is a group of cells that have the same function.

Answers

Answer:

it's true

tissues are group of similar cells the have Common faction.

many organs work together to accomplish a common purpose is called an organ system

What happen after you drink mineral water, does it go to kidney and how it get removed

Answers

Mineral water poses no threat to your health and is processed through the kidneys like any other beverage. In fact, there are experimental studies showing mineral water’s potential to help kidney stone sufferers:

“It is concluded that mineral water containing calcium and magnesium, such as that used in this study, deserves to be considered as a possible therapeutic or prophylactic agent in calcium oxalate kidney stone disease.”
Source: https://pubmed.ncbi.nlm.nih.gov/9096270/

Answer:

dont know hope it helpsjcjdjc

Some animals have an organ called the gizzard. The gizzard is muscular and helps to crush up hard food. Earthworms and many birds, including chickens, have gizzards. Chickens swallow small rocks that help the gizzard to grind up food. Did plant-eating dinosaurs have gizzards too? No one has found an actual dinosaur gizzard, but they have found small piles of round rocks inside dinosaurs’ ribcages.

Based on its function, the gizzard is part of the
system.

Answers

Answer:fg

Explanation:

Bhuhhhfvg

PLEASE HELP!!! URGENT, ILL GIVE YOU BRAINLIEST!!!

Using the example of the digestion of food in the human digestive system, explain why enzymes are
important for life processes.

-Explain-
NO LINKS PLEASE!!!!!

Answers

Answer:

Digestive enzymes play a key role in breaking down the food you eat. These proteins speed up chemical reactions that turn nutrients into substances that your digestive tract can absorb. Your saliva has digestive enzymes in it. Some of your organs, including your pancreas, gallbladder, and liver, also release them.

When rocks and minerals are worn and broken down into small pieces by water, wind, or ice, the resulting particles are called ?

Answers

Sand i think? Maybe dust tho if sand isnt an option

Explanation:

The resulting particles are called sediments.

Rocks and minerals are disintegrated by agents of weathering such as water, glacial (ice) and wind. When these agents of weathering act on rock and minerals, they break down into small particles. These small pieces of weathered rocks and minerals is what is called sediments.

Sediments are pieces of weathered materials from rocks and minerals which can be carried by agents of erosion and deposited in another location.

Thus, the resulting particles from the breakdown of rocks and minerals are called sediments.

Learn more about sediments here:

https://brainly.com/question/11316458

Help me please fill in the blank for conclusion don’t have a lot of time!

The purpose of this experiment was to find out how _________ affects _____________.

Answers

The density of a liquid affects its properties and how it interacts with other liquids.

define and give an example of conduction and convection

Answers

Answer:

Conduction: This is a flow of heat by direct contact. Heat travels from a warmer object toward a colder object.

Convection: This is a transfer of heat by mixing a fluid. Convection occurs within liquids and gases. Examples include boiling water and when warm water mixes with cold water.

OAmalOHopeO

What is a tide?

A.an extreme pull from the gasity of the Sun

B.something that happens to the ocean every two days

C.a cyclical pattern of temperatures in seas and oceans

D. a continua rise and fall of water in seas and oceans

Answers

Answer:

D. a continuous rise and fall of water in season oceans

question 2
Two abiotic resources that affect an ecosystem are:

A. temperature and animals
B. plants and animals
C. water and bacteria
D. soil and water

Answers

B. Plants and animals
Answer: B

Explanation: because i am correct.

Question 9 of 10
Which is not a drawback of using fossil fuels?

Answers

Answer:

is there a picture? or maybe some options?

Explanation:

Answer:

Answer: A) They release radioactive waste. Explanation: Fossil fuels are non renewable resources do not release radioactive wastes / materials, but they do release greenhouse gases, causing air pollution.

I'm giving my 1532 points away.

Identify the characteristics of animal-like protists. Check all that apply.
stationary
able to move using specialized structures
typically autotrophs
unicellular


(Answers: able to move using specialized structures, unicellular)

Answers

Answer:

able to move using specialized structures

Explanation:

Animal like protists have ability to move with short cilia and flagella. And they get energy from other source. Explanation: Euglena can moves through flagella and can produced its own food.

lol thanks.

Answer:

able to move using specialized structures, unicellular

Explanation:

easy

Help please someone please what is the answer

Answers

This is true. Only 3% is fresh water.

Answer:

True

Explanation:2.5% is in glaciers, polar ice caps, and the atmosphere. The other 0.5% is available.

The following table describes some biotechnological processes.

Biotechnological Processes
Process Description
1 Producing offspring that have identical DNA as one parent
2 Crossing a high-yielding fruit variety with a high-vitamin variety
Which biotechnological processes are described in the table? (3 points)

a
Both processes describe cloning.

b
Both processes describe genetic engineering.

c
Process 1 describes cloning and process 2 describes artificial selection.

d
Process 1 describes artificial selection and process 2 describes cloning.

Answers

Answer:

c . Process 1 describes cloning and process 2 describes artificial selection.

Explanation:

Process 1 describes cloning because offspring is produced that are similar to its parent and we know that in cloning, the offspring is identical to their parents while on the other hand, process 2 describes artificial selection because crossing between a high-yielding fruit variety with a high-vitamin variety is done which is only possible through the intervention of humans.

Soil organisms, such as mycorrhizal fungi, impact the rate of succession in ecosystems. Mycorrhizal fungi have a mutualistic relationship with various species of plants and increase the plant growth and survival. Sand dunes often lack mycorrhizal fungi, and a researcher wanted to determine the effect of adding mycorrhizal species to sand on disturbed beaches on grass growth. The researcher set up various mycorrhizal communities at disturbed beaches in different locations on the east coast of the United States. Identify the independent variable in the study.

Answers

Answer:

The amount (number) of mycorrhizal fungi

Explanation:

In a scientific experiment/study, the independent variable is the variable that isn't changed by other variables, while the dependent variable is the variable that is being measured during the experimental procedure. The independent variable is manipulated by the researcher (in this case, the amount of mycorrhizal fungi), thereby affecting the dependent variable (in this case, grass growth). In consequence, a variable is dependent because it 'depends' on the independent variable.

What is the first thing to look for when reviewing a
website with an ".edu" address?
A. Whether the site has been updated recently
B. Whether the site was written by professors
or students
C. Whether the content has been peer
reviewed
D. Whether the site is biased toward the
products or services the company provides

Answers

Answer: I think the answer is B.

Explanation:

what is food poisoning​

Answers

Explanation:

Food poisoning is a illness that can caused by poisonous or contaminated food.

All organisms in the kingdoms Eubacteria and Archaebacteria ____________?
A.multicellular organisms.

B.are autotrophs

C.prokaryotes.

D.are heterotrophs

Answers

Answer:

C

Explanation:

A prokaryote is a typically unicellular organism that lacks a nuclear membrane-enclosed nucleus.

I think the answer is C

Why is mitosis necessary during the development of a human?

Answers

Answer:

Mitosis is a way of making more cells that are genetically the same as the parent cell. It plays an important part in the development of embryos, and it is important for the growth and development of our bodies as well. Mitosis produces new cells, and replaces cells that are old, lost or damaged.

Explanation:

How do fossils show evidence for evolution?

a. They show evidence of species that are now extinct

b. They are the primary source of evidence for natural selection

C. They show that ancient species share similarities of those alive on Earth today

d. Both A and C

Answers

D both a and c sounds correct

make a cell rap song?​

Answers

Answer:

Ayee

I haven't made this one but i know it (If u wanna listen to it just search up Cell City) :

One night in cell city

We're gonna dance until we see the sunlight

The nucleus, like city hall

Holds the cell's information

Mitochondria, a power plant

In charge of energy creation

The Golgi apparatus is like post office

It packages materials and moves them

The ribosome, like a factory

Creating proteins so the cell can use them

When you are tanning yourself on the beach, which part of the atmosphere protects you from the harmful rays of the
sun?
A) stratosphere
B) troposphere
C) mesosphere
D) ionosphere
E) chronosphere

Answers

Answer:

b troposphere

Explanation: The Troposphere is level of atmosphere closest to Earth. The Ozone Layer is the part of the atmosphere that protects us from harmful UV rays.

True or False: Sustainability focuses on reducing the amount of nonrenewable resources used, which prevents the depletion of natural resources.

Answers

This is false, I don’t know if I answered on time but I think it’s false

During a solar eclipse does Earth casts a shadow on the Moon or does the Moon cast a shadow on the earth?

Answers

Answer:

the Moon casts a shadow on the earth.

The moon casts 2 shadows on the Earth
Other Questions
Which number sentence is always true? Select all that apply.negative + negative = negativepositive - negative = negativenegative + positive = positive.positive - positive = positivepositive + positive = positive.negative - positive = negative What are the components within a DNA molecule g If nominal GDP is $4,000 billion and the amount of money demanded for transactions purposes is $800 billion, it can generally be concluded that Multiple Choice the asset demand for money is $3,200 billion. the total demand for money is $4,800 billion. on average, each dollar will be spent five times a year. the supply of money needs to be increased to meet the demand. Solve the simultaneous equationsy = 3 2xx2 + y2 = 18Show clear algebraic working. Suppose a 118kg watermelon is held 5m above the ground before sliding along a frictionless ramp to the ground. How high above the ground is the watermelon at the moment it's kinetic energy is 4,610J Which sentence from the contract shown below refers to consideration?Contract for renovation of houseThe first party, Mr. Alfred Higgins, commissions the work of the second party, PreSense Designs.The second party shall renovate the house of the first party as per the designs attached herewith.The second party should commence the required renovation work not later than 16th October 2014. The work shall be finished within two months from the date of commencement.The second party shall receive $1000 on completion of the work, as per design, from the first party.The first party holds the right to decrease the amount payable, if the second party does not complete the work within two months from the date of commencement.SignedFirst party (Sign here)Second party (Sign here) The poem on the Statue of Libertys base conveyed a welcoming message to immigrants who arrived at Ellis Island in the early 1900s. But immigrants did not find life in the United States easy, and they often felt unwelcome.Suppose you are a teenager who entered the United States at Ellis Island in 1910. Write a letter to your cousin back home about your first year in the United States. In your letter, write aboutthe opportunities you had.the challenges you faced.your impressions of the United States.Convey your ideas clearly, using standard English. Vaughn Manufacturing acquires a coal mine at a cost of $1920000. Intangible development costs total $354000. After extraction has occurred, Vaughn must restore the property (estimated fair value of the obligation is $183000), after which it can be sold for $208000. Vaughn estimates that 5000 tons of coal can be extracted. What is the amount of depletion per ton What is Kennedys answer to the question Why the moon what can we learn from the woman of South Africa that took part in the march heres the second one its the same one as the last one this person just put a link so I cant report it for some reason Help me out! I need this!!!! Brainliest answer and 15 points! HELP ME PLEASEEEEEEEEEEEEEEEE Pleaseeeeee helpppppp i will mark you brainlist A bus makes a stop at 2:30, letting off 10 people and letting on 3. The bus makes another stop ten minutes later to let off 2 more people. How does the number of people on the bus after the second stop compare to the number of people on the bus before the 2:30 stop? n 1960, an invasive species of fish was introduced into the stable ecosystem of a river. Since then, the population of a native fish species has declined. This situation is an example of an 1) Ecosystem that has recovered 2) Ecosystems are altered through the activities of humans. 3) Environmental impact caused by physical factors 4) Ecological niche without competition please help me!!!! im so bad a mathhhh PLZ HELP !!!!!!Biomes found on the land areatmosphere aquatic terrestrial 32. [Problem Solving 2] *On Martha's 9th birthday, her mothermade a cake which had the digits 0 to 9around the edge in red icing. Using theguidelines below, her mother cut thecake into 3 pieces so that the numberson each piece added to the same total.Mark the cuts. What fraction of thewhole cake was the largest piece? Which of the following statements regarding cultural views of postpartum activities are accurate? Checkall that apply.Some cultures believe in limiting a woman's activities for one month followingchildbirth.Some cultures embrace and accept postpartum depression.Some cultures believe postpartum depression to be a shameful experience.Most cultures do not allow women to rest after childbirth.