The activity of the pyruvate dehydrogenase complex is also controlled by phosphorylation. Pyruvate dehydrogenase kinase (PDH kinase) catalyzes the phosphorylation of a specific Ser residue on the E1 subunit of the enzyme, rendering it inactive. Pyruvate dehydrogenase phosphatase (PDH phosphatase) reverses the inhibition by catalyzing the removal of this phosphate group. The PDH kinase is highly regulated and its activity is influenced by various cellular metabolites. Indicate whether the following would activate or inhibit PDH kinase:
Inhibit or activate PDK?
NAD+ activate
NADH inhibit
coenzyme A activate
acetyl-CoA inhibit
ADP inhibit
Did I answer these correctly?

Answers

Answer 1

Answer:

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Explanation:

Pyruvate dehydrogenase kinase, PDK is an enzyme which acts to inhibit the activity of the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. It mechanism of action is by catalyzing the phosphorylation of a specific Ser residue on the E1 subunit of the pyruvate dehydrogenase complex, rendering it inactive. By inhibiting the activity of the pyruvate dehydrogenase complex, PDK will decrease the oxidation of pyruvate to acpcetyl-coA and CO₂ in the mitochondria and increase the conversion of pyruvate to lactate in the cytosol.

Since pyruvate dehydrogenase complex is activated by either an increase in the concentration of one or more of ADP, NAD+ or CoA-SH, its inhibitor pyruvate dehydrogenase kinase is inhibited by ADP, NAD+, CoA-SH and pyruvate. However, PDK is activated by increase in the concentration of ATP, NADH and acetyl-CoA.

Therefore, the correct answers are:

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)


Related Questions

Ernest was looking at the following diagram of a cell. Which statement best explains how he should classify the cell?

A) He should classify the cell as a plant cell because it has a cell membrane.
B) He should classify the cell as an animal cell because it has a flagellum.
C) He should classify the cell as a plant cell because it has cytoplasm.
D) He should not classify the cell as either a plant cell or an animal cell.

Answers

Answer:   Its d

Explanation:

which of the following is an example of a complementary base pair in DNA?
a. A-G
b. T-C
c. A-U
d. C-G

Answers

Answer: d. C-G

Explanation:

DNA or deoxyribonucleic acid is a structure which is common in every living organism. The two strands of the DNA are held together by base complementarity between the nitrogenous bases these bases are held by hydrogen bonding. Adenine always pairs with thymine by a triple hydrogen bonding and cytosine is always forms a pair with that of guanine by a double hydrogen bonding. So, in this given situation cytosine or C will show complementarity with that of guanine or G in a DNA structure helping in linking the two strands of DNA to form a single integrated double helical structure.

Answer: D.c-g

Explanation:

Which of the following does the frog represent? A. Primary producer B. Primary consumer C. Secondary consumer D. Decomposer

Answers

Answer:

Primary Consumer

Explanation:

Because it eat directly from the plants, which are primary producers

(3)
2.1
2.2
23
Provide labels for structures A, B and
State THREE functions of D
Fertilisation usually takes place at Y. Why wil
a blockage at X
2.3.1 Prevent fertilisation at Y
2.3.2 Not necessarily lead to infertity
(2)
3. Study the graph below which shows the menstrual
cycle and the influence of the different hormones on
it.​

Answers

Answer:

i am pro i am pro i am pro i am pro

all of the following about gastrin are true except

Answers

Answer: Gastrin is released into the lumen of the stomach.

plzz mark brainliest

Explanation:

A. homeotherm
would
QKeep its body temperature constant regardless of the environment.

B.Rely on the environment for its heat.

C.Allow its body temperature to fluctuate with the environment

Answers

Answer:

Keep its body temperature constant regardless of the environment. its A

What is true for an energy resource with a low net energy?

Answers

Answer:

An energy resource with a low or negative net energy can have a hard time competing in the marketplace with other energy alternatives that have medium to high net energy yields unless it receives financial support from the government (taxpayers) or other outside sources.

Explanation:

- Eijiro <3

Which gland is enlarged in a young child and what is the main function of the hormone it secretes?
O A) Pineal – seasonality and salt resorption
B) Thyroid - metabolism
C) Thymus - immune system development
D) Pancreas - calcium storage
E) Adrenal – secondary sexual characteristics

Answers

Answer:

C

Explanation:

The thymus produces and secretes thymosin, a hormone necessary for T cell development and production. The thymus is special in that, unlike most organs, it is at its largest in children.

Answer:

The right answer is option C, thymus.

Thymus helps in immune system development. Its located behind sternum and helps in maturation of T lymphocytes.

Where does ocean salt come from?
a. macrofungi
b. sporophere
c. roomology
d. mycology​

Answers

Ocean salt primarily comes from the evaporation of seawater, leaving behind the dissolved minerals and salts. It is not derived from macrofungi, sporophere, roomology, or mycology.

Ocean water contains dissolved salts and minerals, which are primarily derived from various sources such as weathering of rocks on land, volcanic activity, and underwater vents.

When the sun's energy heats the surface of the ocean, it causes the water to evaporate. Evaporation is the process by which water molecules escape into the atmosphere as water vapor.As the water vapor rises, it leaves behind the dissolved salts and minerals, which become concentrated in the remaining seawater.Over time, with continued evaporation, the concentration of salts and minerals in the remaining water increases.Eventually, the remaining water becomes supersaturated with salts, leading to the formation of salt crystals. These crystals can take the form of various salt compounds, such as sodium chloride (common table salt) and others.These salt crystals may precipitate and settle at the bottom of the ocean or accumulate in saltwater bodies, such as salt flats or salt pans.

Therefore, ocean salt is primarily a result of the evaporation of seawater, concentrating and leaving behind dissolved salts and minerals. It is not derived from macrofungi, sporophere, roomology, or mycology.

For more such question on evaporation

https://brainly.com/question/20459590

#SPJ8

What are unicellular organisms
with
examples
what is the function of plasma membrane​

Answers

The plasma membrane, or the cell membrane, provides protection for a cell. It also provides a fixed environment inside the cell. And that membrane has several different functions. One is to transport nutrients into the cell and also to transport toxic substances out of the cell.

A series of Hfr strains that have genotype m+ n+ o+ p+ q+ r+ are mixed with an F− strain that has genotype m− n− o− p− q− r−. Conjugation is interrupted at regular intervals and the order of the appearance of genes from the Hfr strain is
determined in the recipient cells.

a. The order of gene transfer for each Hfr strain is:_________
b. What is the order of genes on the circular bacterial chromosome? For each Hfr strain, give the location and direction of the F factor in the chromosome

Answers

my brain can't process this lol

which of the following is part of the digestive system? Adrenal gland, Ovary, Striped muscle, or tounge.

Answers

Answer:

tongue

Explanation:

Oh boy, what is this. So striped muscle isn't guaranteed to be part of the digestive system, and the adrenal gland just doesn't sound like it would be part of the digestive system. The Ovary is a hard no, to the tongue is the only one left.

if this is wrong let me know

hope this helps:)

What does inflammation lead to allow white blood cells to find the
infection and the release of cytokines?

Answers

because then you get a infection

You've been experiencing acid indigestion lately, and you'd like a quick fix for the problem. You do a little research on the Internet and discover that your problem is caused by excess stomach acid. In the pharmacy aisles, however, you're having a little trouble deciding what to purchase to address the problem. At the pharmacy counter, the clerk recommends that you purchase PEPCID AC or Alka-Seltzer tablets. You want to design an experiment to compare the effectiveness of Pepcid AC tablets and Alka-Seltzer tablets. Which of the following facts would be least likely to complicate your experiment and the analysis of your results?

a. PEPCIO AC and Alka-Seitzer tablets contain different ingredients.
b. PEPCID AC and Alka Seltzer tablets contain different concentrations of the antacid drug.
c. The recommended dosage for PEPCID AC and Alka-Seltzer tablets is different.
d. PEPCIO AC and Alka-Seltzer tablets are sold in different countries throughout the world,

Answers

Answer:

d. PEPCIO AC and Alka-Seltzer tablets are sold in different countries throughout the world.

Explanation:

When there is excess acid in the stomach then Alka-Seltzer tablet can be used. The Ph level of these tablets is higher than 7 because acidic reaction need to be stopped with an introduction of base.

In terms of daily hassles, what age differences have been found?
A) Elderly individuals are much more strongly affected by daily hassles like
grocery shopping, doctor's appointments, and bad weather.
B) Young individual's daily hassles are more commonly related to money
problems, while older individual's daily hassles are more commonly due to
interpersonal conflict.
C) There are no significant age differences in either the frequency or cause of
daily hassles.
D) Older individuals are more likely to cope with daily hassles by becoming
angry, while younger individuals are more likely to respond to daily hassles by
withdrawing from others.

Answers

Answer:

Option B is the correct representation of differences in terms of daily hassles between the old and young people

Explanation:

As compared to old people, young people carry heavy burdens in terms of stress exposure. The daily activities such as house hold works, grocery shopping etc become a burden for young ones while the old age people are primarily affected by interpersonal conflicts, physical pain etc. Exposure of such daily hassles causes deterioration of health of both the young and old ones.

Hence, option B is correct

room temperature for phosphorus​

Answers

Explanation:

0.5digre celcious is our temperature ️ know

what kind of animals are the best suited to life in a tundra

Answers

Answer:

Muskox, Arctic Wolf and Brown bear

Explanation:

Answer:

Tundra biome is also called as "treeless mountain tract" and the animals best suited to this type of climate are Arctic fox, Muskoxen, snow owl and polar bear.

If all of your cells have the same complete set of DNA why do different cells in different proteins

Answers

Why do we have different cells in our bodies if every cell has the same DNA?

The genome of a cell contains in its DNA sequence the information to make many thousands of different protein and RNA molecules. A cell typically expresses only a fraction of its genes, and the different types of cells in multicellular organisms arise because different sets of genes are expressed.

(I need help will make brainlyest) Which shows the correct order for the classification of species------------------

A) Domain, Kingdom, class, Order, Phylum, Family, Genus, and species-------------------------

B) Domain, Kingdom, Phylum, class, order, Family, Genus, and species--------------------------

C) Domain, Kingdom, Phylum, Class, Order, Family, Species, and Genus------------------------

D) Domain, Kingdom, Phylum, class, order, family, genus, species----------------------------------

Answers

i believe the answer is B thank you troy and abed

How many proton , neutrons , and electrons are there barium ?

Answers

Answer:

137.327 atomic mass units

hope this helps

Explanation:

Answer:

56 protons, 81 neutrons and 56 electrons

Explanation:

hope that helps

state two functions of cell sap​

Answers

Explanation:

The liquid inside the large central vacuole of a plant cell that serves as storage of materials and provides mechanical support, especially in non-woody plants. It has also a vital role in plant cell osmosis. (2) The cytosol, which is the watery fluid component of the cytoplasm.

Introduction : Scientists who study earth's layers are called geologists. Since they cannot see inside the earth, they use geological clues to help them. These clues are gathered from activities such as volcanoes and earthquakes. From these clues , geologists make inferences about what the inside of Earth actually looks like.
Question: Name the main layers of the Earth from the inside to the surface.

Answers

Answer:

Inner core, the outer core, the mantle, and the crust.

Word Bank :
Condensation

Evaporation

Precipitation

Sublimation

Transportation

Using the works from the Word Bank, explain how the water cycle works. You must using complete sentences and using all of the words in the word bank. Please write you answer in 5 or more sentences using words used from the word bank.​

Answers

I hate these scammers smh- sublimation

What is the BEST description of the beginning of secondary succession?
(a)Soil is already present.
(b)It begins on rock formations.
(c)Plants are already present.
(d)Pioneer species appear.

Answers

Answer:

C,,, Plants are already present.

Explanation:

Answer:

Plants are already present.

Explanation:

Mutation happens during which of the following processes?
D Protein synthesis


A DNA transcription


B DNA replication


CTranslation

Answers


Answer
B: DNA replication

hello people of brainly

Answers

Answer:

a scientist should observe the natural world without changing or destroying it

Why were Domains added to the classification system after the time of Linnaeus?

Answers

Answer: With the development of powerful microscopes, scientists discovered many single-celled organisms that didn't fit into any of Linnaeus' kingdoms. As a result, a new taxon, called the domain, was added to the classification system.

Explanation:

HELP ME I NEED THIS DONE ASAP I DON'T HAVE TIME TO COMPLETE IT
50 points for whoever can do this. thanks! :)
(why is no one helping me??? Please!)

Answers

Answer:

The reason why no one is helping you is because you never asked a question

Explanation:

Did I get it right?

Answer:

the answer is nothing because u have no question for someone to answer and your point is nothing thats why no one is helping u

Explanation:

Anyone Know?
i need fast

Answers

that was correct. it was letter choice b

Describe how the EMG signal (a voltage) arises from muscle activity

Answers

Answer: The EMG signal is a biomedical signal that measures electrical currents generated in muscles during its contraction representing neuromuscular activities. The nervous system always controls the muscle activity (contraction/relaxation). ... EMG signal acquires noise while traveling through different tissues. EMG signals are recorded by placing electrodes close to the muscle groups. When the muscle is activated, the length of the muscle decreases and the muscle, skin and electrodes move with respect to one another. At that time, the electrodes will show some movement artifacts

Explanation:

EMG signals are recorded by positioning electrodes close to the muscle groups. It is the arrangement that helps in the monitoring of EMG signals from muscle activity.

What do you mean by EMG signals?

EMG signals may be defined as a biomedical signal that estimates electrical currents provoked in muscles during their contraction illustrating neuromuscular activities.

When the muscle is stimulated for any mechanism, the length of the muscle declines, which leads to the muscle, skin, and electrodes moving with regard to one another.

The EMG signals always arise from the electrical activity of the muscle fibers which are stimulated during the time of contraction.

Therefore, EMG signals are recorded by positioning electrodes close to the muscle groups. It is the arrangement that helps in the monitoring of EMG signals from muscle activity.

To learn more about EMG signals, refer to the link:

https://brainly.com/question/14787272

#SPJ2

Other Questions
On what geologic feature is the generation of hydroelectric power primarily based in Ontario?The Sudbury Impact StructureThe Mid Continent RiftThe Niagara EscarpmentThe Abitibi Greenstone Belt P12-7A. Statement of Cash Flows (Direct Method) Refer to the data given for the North Company in Problem P12-2A. Required Calculate the change in cash that occurred during 2019. Prepare a statement of cash flows using the direct method. a. b. LO4 (APF 12A X a. Cash, December 31, 2019 Cash, December 31, 2018 Cash increase during 2019 Supporting computations: Cash received from customers: Given in Data Set on the balance sheets Insert lines as necessary $770,000 sales + $7,000 A/R decrease = 777,000 Cash paid for merchandise purchased: Cash paid to employees: SSS $ $ Example Cash paid for advertising: Cash paid for interest: Sale of land: Sheet2 Purchase of equipment: Issuance of bonds payable: Sheet3 Sheet4 Sheet5 I Purchase of treasury stock: Other Analysis Accumulated depreciation increased by $24,000, which is the amount of depreciation expense Common stock account balance did not change Retained earnings decreased by $25,000, which is the amount of net loss. I ett Sheet2 North Company Cash flow from operating activities Cash received from customers Statement of Cash Flows For Year Ended December 31, 2019 Cash paid for merchandise purchased Cash paid to employees Cash paid for advertising Cash paid for interest Cash provided by operating activities Cash flow from investing activities Sale of land Purchase of equipment Cash used by investing activities Sheet3 Cash flow from financing activities Sheets + Sheet4 I fx B D E Cash provided by operating activities Cash flow from investing activities Sale of land Purchase of equipment Cash used by investing activities Cash flow from financing activities Issuance of bonds payable Purchase of treasury stock Cash provided by financing activities Net increase in cash Cash at beginning of year Cash at end of year F G H IS J The solution of the system of differential equations:dx / dt = -6x +5y + tdy / dt = -5x +4y + 1 Sherrill Winery sells two vintages of wine. The Albertson wine sells for $30 a bottle and annually they sell 13,000 bottles. The Bumphrey wine sells for $90 a bottle, but they only sell 3,000 bottles per year.The company is considering offering a new, mid-priced wine called Calvinhall. They think they can sell this wine at $60 a bottle, and anticipate they can sell 2,000 bottles per year. However, they also think it will reduce annual sales of Albertson by 1,000 bottles per year and reduce sales of Bumphrey by 500 bottles per year.When estimate the cash flows for the Calvinhall wine, what amount should they use for the annual sales?Multiple Choice$45,000$195,000$120,000$705,000$660,000 Suppose that the cross-price elasticity between good x and y is 25 and that the price of good y increases. Which of the following statements is true? OA. The Price Consumption Curve (PCC) between the goods is downward sloping. OB. Goods x and y are demand substitutes. OC. Demand for good x increases after the price change O D. Goods x must be a normal good OE. None of the above Colection What is the yield to maturity of a bond with a par value of $1000, makes coupon payments semi-annually, has a 10% coupon rate, has 12.5 years until maturity, and is currently selling for $1158.22? Num Identify the population and propose an appropriate sample for the following survey question: How do the parents of the students at Rosedale Academy feel about visiting Canada? Employee satisfaction would be an example of measuring which perspective of the balanced scorecard? A) Financial B) Customer C) Learning and growth D) Internal business draw a flowchart showing the general logic for totaling the values in an array. ( Power Corporation owns 75 percent of Surge Companys stock; no intercompany purchases or sales were made in 20X4. For the year, Power and Surge reported sales of $330,000 and $230,000 and cost of goods sold of $170,000 and $109,250, respectively. Powers inventory increased by $32,000, but Surges decreased by $13,000. Powers accounts receivable increased by $16,000 and its accounts payable decreased by $11,000 during 20X4. Surges accounts receivable decreased by $9,000 and its accounts payable increased by $6,000.Required: Assuming there were no other cash flows from operations, using the direct method of computing cash flows from operating activities, compute the following:a) Cash received from customersb) Cash payments to suppliersc) Cash flows from operating activities Which of the following are unique characteristics of ape hands and feet (choose ALL that apply): Opposable thumbs and sometimes an opposable big toe Precision grip Nails instead of claws Inflexible wrists What are the unique characteristics of platyrrhine monkeys? (choose ALL that apply) Broad flat noses with nostrils facing outwards Narrow noses with nostrils facing downwards Prehensile tail Ischial callosities What are the characteristics of catarrhine monkeys? (choose ALL that apply) Broad flat noses with nostrils facing outwards Narrow roses with nostrils facing downwards Prehensile tail This is something only New World Monkeys can do Ischia caloties A car accelerates from rest to 35m/s in a distance of 88 m. What was its acceleration in m/s2, assumed constant? Consider the following chromatographic data. Length of column 15.3 cm Flow rate 0.563 mL/min Volume of mobile phase 2.43 mL Volume of stationary phase 0.195 mL Base Peak Width (minutes) Retention Time (minutes) 0.53 1.73 2.64 3.02 8.41 Component Nonretained 0.45 0.78 1.22 1.45 Calculate the following a. partition coefficient (K) for peak B b. H based on peak C c. resolution of peaks B and C d. k' for component D Question 6 [2 marks] Which of the following statements is incorrect? a. The duration of this Treasury bond will be higher if its coupon rate is higher. b. We can use the duration of this Treasury bond to measure its price sensitivity. c. The duration of this Treasury bond will increase if the yield rate at purchase is lower. d. The purchase price of this Treasury bond will decrease, if this Treasury bond is subject to a 30% tax on both interest and capital gains. For the year ended 30 June 2022, the following information is available for X-ray Ltd: 2022 2021 Dividend receivable 5,200 4,400 Land 240,000 100,000 Buildings 1,200,000 500,000 Accumulated depreciati Select the correct statement regarding commodity (or excise) taxes. The reduction in consumer and producer surplus associated with a commodity tax is equivalent to the tax revenue collected. The burden of a tax is unrelated to who actually pays money to the government. Regardless of who writes a check to the government, the burden of commodity taxes is shared equally by buyers and sellers. From the perspective of buyers, taxes imposed on firms are preferable to taxes imposed on buyers, because firms ultimately pay a larger share of these types of taxes. Select the correct statement regarding tax wedges. Tax wedges are smaller when commodity taxes are imposed on buyers. The size of the tax wedge is unrelated to elasticity. Tax wedges are larger when commodity taxes are imposed on buyers. Tax wedges are larger when supply is more inelastic than demand. Tax wedges are larger when demand is more inelastic than supply TEST REVIEW(Show all work, including formula and units for full credit.)a) A plane has a speed of 550 km/h west relative to the air. A wind blows 35 km/h east relative to the ground. What is the planes speed and direction relative to the ground?b) A motorboat heads due west at 18 m/s relative to a river that flows due north at 4.0 m/s. What is the velocity (both magnitude and direction) of the motorboat relative to the shore?c) Martin is riding on a ferry boat that is traveling west at 3.2 m/s. He walks south across the deck of the boat at 0.54 m/s. What is Martins velocity relative to the water?d) An airplane flies due east at 440 km/h relative to the air. There is a wind blowing at 65 km/h to the southwest relative to the ground. What are the planes speed and direction relative to the ground? Which of the following strongly influences the success of coordination?acknowledging information and coordination "voids" at the geographic combatant command and joint task force headquarters (WRONG) to persuade my audience that the newly developed crispr genetic technology is morally unjustifiable"" is a specific purpose statement for a persuasive speech on a question of A car travels 40 kilometers at an average speed of 80 km/h and then travels 40 kilometers at an average speed of 40 km/h. What is the average speed of the car for this 80 km trip?(1) 40km/h(2) 45km/h(3) 48km/h(4) 53km/h