what changed in metabolic pattern would result from a mutain in the muscle carnitine acyltransferase 1 in which the mutant protein has lost its affinity for malony

Answers

Answer 1

Malonyl-CoA would no longer hinder fatty acid entry into the mitochondrion and beta-oxidation, potentially leading to a futile cycle of cytosolic fatty acid synthesis and mitochondrial fatty acid breakdown.

When there is no food intake, the liver produces ketones by breaking down fatty acids. This safeguards the brain, which cannot oxidize fatty acids during the nocturnal fast or longer periods of starvation. Malonyl-CoA, the substrate of fatty acid synthesis, was discovered to be an inhibitor of fatty acid oxidation in 1977. Subsequent experiments confirmed this discovery and advanced our comprehension of molecular metabolism.

During the overnight fast and, more relevantly, during prolonged fasting or starvation, the decrease in malonyl-CoA concentration saves lives. It can, however, be fatal in uncontrolled type 1 diabetes, where significantly increased concentrations of long-chain fatty acids shift the chemical state from modest ketosis to full-blown ketoacidosis if not treated.

Individuals with genetic deficiencies in the enzymes that regulate carnitine levels and fat oxidation face a more significant problem than transient lowering of malonyl-CoA.

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Related Questions

is mayonnaise real? I heard about it on twitter :/

Answers

no because it just isn’t

Answer:

Real question is: is mayonnaise an instrument?!

Explanation:

Give brainiest or suffer the consequences

HELP!!!! 50PTS!!! AND WILL BE MARKED BRAINLIEST!!!!


Based on the information in the data table and the cladogram shown below, which of the following best describes the evolutionary history of lizards? (4 points)

Amniotic membrane Bipedal locomotion Hair Jaws Lack of tail Lungs
Gorilla X X X X X X
Human X X X X X X
Lamprey
Leopard X X X X X
Lizard X X X
Salamander X X
Shark X

Image depicts a cladogram with lamprey, shark, salamander, lizard, leopard, gorilla, and human represented. Shark diverges from lamprey with the introduction of jaws. Salamander diverges from shark with the introduction of lungs. Lizard diverges from salamander with the introduction of amniotic membrane. Leopard diverges from lizard with the introduction of hair. Gorilla diverges from leopard with the absence of a tail. Human diverges from gorilla with bipedal locomotion.

They are more closely related to lampreys than they are to leopards.
They evolved into a separate species as a result of the presence of an amniotic membrane.
They have jaws and lungs but lack an amniotic membrane.
They share a more recent common evolutionary ancestor with salamanders than they do with sharks. I think is D

Answers

Answer:

D. They share a more recent common evolutionary ancestor with salamanders than they do with sharks.

Explanation: Just took the test and got it correct

The cladogram shows that lizards share a more recent common evolutionary ancestor with salamanders than they do with sharks.

What is cladogram?

A cladogram is a diagram in the form of a tree wgich shows the evolutionary relationship between organisms based on similarities shared in structure or function.

The cladogram given show that sharks, lizards and salamanders have a common origin but that Lizard diverges from salamander with the introduction of amniotic membrane.

Therefore, Lizards share a more recent common evolutionary ancestor with salamanders than they do with sharks.

Learn more about cladogram at: https://brainly.com/question/12275760

How does the process of meiosis reduce the number of chromosomes in reproductive cells?

Answers

Meiosis is a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells. ... The process results in four daughter cells that are haploid, which means they contain half the number of chromosomes of the diploid parent cell.

What would be an individual with a genotype of XY would be ?

A. not possible
B. a male
C. a dwarf
D. a female

Answers

The answer is B, a male

Field mustard is an annual plant that grows wild in many regions of the world. It has small yellow flowers and is pollinated by insects. Field mustard has to flower and produce seeds to give rise to the next generation. Southern California experienced a severe drought between 2000 and 2004. Plants that flowered earlier reproduced. Those that flowered later died without producing seeds. This led to more early-flowering field mustard plants. This change in population characteristics took only a few generations.
How do you think scientists discovered that the flowering time of the field mustard had changed?
I will mark you as brainliest!!!!!!!!!!

Answers

Answer:

Mustard adapts quickly to climate fluctuations

Explanation:

Instead, the post-drought seeds gave rise to plants that flowered earlier than those of the pre-drought seeds, even in the greenhouse, confirming that the shift in flowering time really was due to an underlying change in the plants' genetic program.

The stable stage that is established in an area as a result of the process of ecological succession is known as the
A) pioneer organism
B) climax community
C) biotic stage
D) heterotrophic community

Answers

Answer:

Climax community

Explanation:

Answer:

B is your answer

Explanation:

What explains two green pea pod plants producing 25% plants with yellow
pea pods? (green is dominant, yellow is recessive)

Answers

Answer:

two heterozygous pairs

Explanation:

the genotype products of Gy and Gy would be GG, Gy, Gy, and yy, making a 25% chance for yellow

The heterozygous pairs are those that have different alleles in the two chromosomes a and a re a set of the dipole individual.  

The 2 green pea pod plants produce 25% of the yellow sea pods where the green is the dominate and yellow is recessive. As the chromosome is inherited in both the parent the gene is same. Thus the dominant green color and yellow pod plants will have a mix of genes.

Learn more about the green pea pod plants producing 25% plants.

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Work is done when you
A .you lift a book
B .you stand on the floor
C .you hold a box
D .you push against a wall

Answers

the correct answer is A. you lift a book

How do organisms extract and utilize the energy from ATP?

Answers

Through the process of cellular respiration, the energy in food is converted into energy that can be used by the body's cells. During cellular respiration, glucose and oxygen are converted into carbon dioxide and water, and the energy is transferred to ATP.

explain the differences between the particles of a pure substance and the particles of a mechanical mixture

Answers

Answer:

A substance is pure if it is a single substance, and it is made up of only one type of particle. If there is more than one substance, and therefore more than one type of particle, it is a mechanical mixture, the particles can be easily distinguished, due to their non-uniform composition. The composition of a mechanical mixture is variable and their components may be separated by physical or mechanical means because they are not chemically bound.

Explanation:

A pure substance is one that has a composition and characteristic properties that do not change, whatever the physical conditions in which it is found; that is, the physical transformations do not affect it. In other words, pure substances will be made up of particles that are identical to each other. Mechanical mixture are the result of the physical union of two or more substances which are called components, these can be elements or compounds, whose particles do not mix uniformly. The components of the mixtures have different properties, such as the state of aggregation, the density or the solubility. These properties allow substances to be identified and facilitate the separation of the components of a mixture, that is, through physical or mechanical processes we can isolate and obtain the components that make up the mechanical mixtures.

plants realease water into the atmosphere by which two processes?

Answers

Answer:

Evaporation and Transpiration

Explanation:

Compare and contrast genetic engineering to the process of natural selection. Select all statements that are true

Answers

Available options are:

1. By selecting the genetic information that is passed on to future generations, genetic engineering is similar to natural selection.

2. Unlike natural selection, genetic engineering selects the organisms most beneficial to the environment.

3. By selecting the genetic information that is passed on to future generations, genetic engineering can happen at a different rate than natural selection.

4. Like natural selection, genetic engineering may be used on all organisms, including humans.

5. The effects of genetic engineering apply only to the organism selected, but natural selection affects the entire population.

Answer:

1, 2, and 3

Explanation:

Given that Genetic engineering is a scientific process of altering the genetic makeup or elements of organisms such that these organisms develop preferable traits.

On the other hand, Natural selection is a process that deals with the impartial selection of traits, that is without human input, thereby making organisms more fitted to their immediate environment.

Therefore, considering the available options, the comparison, and contrast of genetic engineering to the process of natural selection are:

1. By selecting the genetic information that is passed on to future generations, genetic engineering is similar to natural selection.

2. By selecting the genetic information that is passed on to future generations, genetic engineering can happen at a different rate than natural selection.

3. Like natural selection, genetic engineering may be used on all organisms, including humans.

Answer:  1, 3, and 4

Explanation: :)

Explain why the BREATHING RATE of students increased after exercise. Include information about what happens at the level of body systems and at the cell.

Explain why the HEART RATE of the students increased after exercise. Include information about what happens at the level of body systems and at the cell.

Answers

Answer:

When exercising, your body uses more oxygen and produces more carbon dioxide and your muscles also need energy to contract because of this your breathing needs to increase.

Hope this helps :D

Answer:

for why the heart rate increase is because during exercise alot energy is used which means alot of oxygen also used for respiration ,the cells need oxygen to meet the demand of energy so breathing rate increase then to transport oxygen faster then the heart rate also increases.

Why do flowers have such colorful petals? *
A. So you can see them at night
B. To trap insects
C. To scare away predators
D. To attract animals for pollination
E. Petals don't have color

Answers

attract animals for pollination

yo i need the correct answer please i’ll give u a brainliest

Answers

Answer:

c.   1 carbon, 4 hydrogen, and 2 oxygen

Explanation:

Yea it’s C coming from the person above

Which of the following statements is correct? Which of the following statements is correct? The sperm and egg have twice as many chromosomes as the parental cells. Geneticists use the terms "son" and "daughter" to distinguish between cells resulting from cell division. Meiosis results in gametes that are used in reproduction. Asexual reproduction requires the production of eggs and sperm.

Answers

Answer:

Meiosis results in gametes that are used in reproduction.

Explanation:

The sperm and egg have twice as many chromosomes as the parental cells. INCORRECT. Sperm and eggs are the gametes, and they have only half the number of chromosomes that can be found in the germ cells or somatic cells. Gametes are haploid, n. Geneticists use the terms "son" and "daughter" to distinguish between cells resulting from cell division. INCORRECT. The term "daughter cells" is used to refer to the products of cell division. "son cells" is not used at all. Meiosis results in gametes that are used in reproduction. CORRECT. Germ cells are the reproductive, diploid cells produced by testes and ovaries. After meiosis, each germ cell produces four haploid cells that are the gametes. Gametes´ destiny is to merge during fecundation, creating a new diploid cell called the zygote. The zygote is a diploid cell that suffers successive mitosis to form the new organism.Asexual reproduction requires the production of eggs and sperm. INCORRECT. Only sexual reproduction needs gametes. Cells that reproduce asexually duplicate their genetic material and cytoplasmic content and then divide, producing a new cell identical to its parental. This is the case of binary fission, for example.  

Retired police captain Gary P. died of an apparent heart attack while scuba diving. Within hours of his death, his wife asked the hospital to retrieve a sample of his sperm. The following year, she became pregnant as a result of in vitro fertilization. Is her son entitled to police department pension benefits based on the information presented in the opening section of the chapter on this case study?'

Answers

Answer:

Yes. He's entitled to have the benefits.

Explanation:

If they conduct a DNA testing and found out that the result is positive between Capt. Gary and the boy. Was he the only child? If not they can also test his siblings if Capt. Gary wasn't able coz he's dead.

And if his mom is lying. I wanted her behind bars.

How does overexploitation of oceans illustrate the tragedy of the commons ?

Answers

Answer: most of the world's ocean area also lies outside the legal jurisdiction of any country, thus, much of it is an open-access resource, subject to overexploitation. mark brainliest

Explanation:

The smallest blood vessels that connect arteries and veins, and allow blood to pick up
and drop off substances with surrounding cells.

Answers

Capillaries are the smallest type of blood vessels and they are how nutrients leave and enter the blood stream

why do birds have short necks? pls help :/

Answers

Most diving birds have (relatively) long necks and shorts legs, although their necks aren't as long as say herons, storks or egrets. Take the common loon for instance. Their necks can be up to half as long as their bodies but their legs are so short and set so far back that they are very awkward on land.

At which of the following locations in the stream was there most likely a discharge of excess organic
matter into the water?

Answers

Answer:

D

Explanation:

Answer:

its actually B not D

Explanation:

When people eat shrimp, they first pull off an outer covering that in life provided protection to the animal. What is this structure?

Answers

Answer:

carapace

Explanation:

the shell which protect the cephalothorax is called the carapace

A little help please..?​

Answers

Answer: True

Explanation: Hope this help :D

Answer : true

Explanation :

When resistant bacteria multiply, what do they pass on to the next generation?

Answers

Answer:

Antibiotic use promotes development of antibiotic-resistant bacteria. Every time a person takes antibiotics, sensitive bacteria are killed, but resistant germs may be left to grow and multiply. Repeated and improper uses of antibiotics are primary causes of the increase in drug-resistant bacteria.

The resistant bacteria can reproduce rapidly because their competition (the non-resistant bacteria) has been destroyed by the antibiotic. When the resistant bacteria reproduce, they produce genetically-identical copies. These copies will all be resistant to the antibiotics.

Hope this helps :)

4
Some toxic compounds are ingested & retained in the tissues. These pollutants pose special
risks to humans and other organisms high on the food chain because of which process?
(3 Points)
Dose-response
o
Carcinogenesis
Biomagnification
Synergism
Threshold effect

Answers

Answer:Biomagnification

Explanation:Cause it’s right fella

Answer:

Biomagnification

Explanation:

Answer could be
A.)3/16
B.)9/16
C.)11/16
Or D.)13/16

Answers

Answer is ab. 9/16 yessssssss

Which statement concerning the climax stage of an ecological succession is correct?
A) It is the first community to inhabit an area.
B) It consists entirely of plants.
C) It persists until the environment changes.
D) It changes rapidly.

Answers

Answer:

C) It persists until the environment changes.

Explanation:

Hope this helps

The development by scientists of a new color in a rose is the result of
O natural selection
artificial selection
descent with modification
O overproduction

Answers

Answer:

Artificial selection.

Explanation:

The development by scientists of a new color in a rose is the result of artificial selection.

Artificial selection

7
1 point
In snapdragon flowers, the combined expression of red and white alleles for flower color produces a third phenotype that is pink. This illustrates incomplete
dominance. Which of the following would be the correct product from a cross between two heterozygous pink snapdragons?
Red
Pink
(RR)
(RW)
R R
R w
1
w (RW) (RW)
White
Pink
R
(RW)
w
2.
(ww)
w (RW)
(RW)
3
All pink flowers
?
1 red, 2 pink, 1 white
4
2 red, 2 white
ОООО
5
2 red, 1 pink, 1 white
1 red, 1 pink, 2 white

Answers

go to photo math it should help

Which of the following correctly shows one path that energy would flow through this ecosystem?
Star grass — termite-wildebeest aardvark
O
Hyena — aardvark impala - harvester ant
О
Grasshopper termite-Warthog hare
O
Red oat grass — termite - wildebeest — lion

Answers

Answer: g

Explanation:

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How did the north and South react to slavery? How long will it take for a radioactive sample to decrease to 25% if its half-life is 11 years? Which is not a test for similarity 1 SSS 2 SAS 3 AAA 4 ASA? Traditional approaches would argue that____is important to a group definition of race but not to a group definition of ethnicity. Which transformations can prove that figures are congruent? What is the median of the following 3 4 5 3 6 7 2? In a chi-square test for ________________ of proportions, we test whether different populations have the same proportion of individuals with some characteristic. What will happen to the chocolate when exposed to heat Why do you think it happen? What 3 system removes carbon dioxide and waste from your cells? What is the mathematical relationship between the velocity of the sound v its wavelength and its frequency f? What is Japanese poetry known for? The main idea of this cartoon is that in the early 20th century Why is the AAA similarity test not necessary? Supply chain management involves the functions of plan - buy - make - deliver. select the best way to describe the decisions made within these four functions.A. The decisions made in these functions happen sequentially: First the Plan Department makes planning decisions. Then the Buy Department makes purchasing decisions. Then the Make Department makes production decisions. And finally, the Deliver Department makes transportation decisions.B. The decisions made in these functions are fragmented and separate from one another. Similar to the way concepts were presented in this course, Supply Chain Management is just a bunch of very small decisions that utilize a variety of tools, techniques, and calculations. Independent managers can use any of these tools, techniques, or calculations to make the optimal decision for the business.C. The decisions made in these functions must be made collaboratively and concurrently (at the same time). Any decision in one area will influence the optimal decision for the other areas. Furthermore, the decisions made in Supply Chain Management must be made with the other functions of the business in mind: Sales, Marketing, Finance and Accounting decisions are also interdependent on the decisions made in Supply Chain Management. When one functional manager would like to change a way that part of the Supply Chain operates, the other functions of Supply Chain will need to coordinate their efforts to support these decisions. The interconnected nature of Supply Chain is one of the features that makes SCM complex - but, for our SCM majors, this is also the feature that makes Supply Chain the most fun. We get to use our creativity to improve the business performance!D. The decisions made in these functions happen independently. Each of the four functions of Supply Chain makes the best decision for their own part of the Supply Chain and when all the pieces come together, everything works out perfectly. A local restaurant advertises that the mode cost of their most popular meals is $8. If the costs of their most popular meals are $7, $8, $8, $15, $15, $16, $17, $18, and $20, which word or phrase best describes this kind of advertising?accurateinaccurateinaccurate and misleadingaccurate, but misleading Q1-Mutual funds provide the following for their shareholders. A. diversification B. professional management C. record keeping and administration D. all of the se options Why is it important in knowing the conceptual definition in research study? 2. which statement about the role that biologic makeup plays with the clients emotional response is most accurate: a california property sold for a $600,000 in a city that does not impose a transfer tax. what is the total transfer tax this property is subject to? Solve the following inequality using the algebraic approach:x + 2 > 3x-8